Cytosolic sensors for pathogenic viral and bacterial nucleic acids in fish

M Mojzesz, K Rakus, M Chadzinska… - International Journal of …, 2020 - mdpi.com
Recognition of the non-self signature of invading pathogens is a crucial step for the initiation
of the innate immune mechanisms of the host. The host response to viral and bacterial …

Grouper MAVS functions as a crucial antiviral molecule against nervous necrosis virus infection

Y Huang, J Zhang, Z Ouyang, J Liu, Y Zhang… - Fish & Shellfish …, 2018 - Elsevier
Mitochondrial antiviral signaling protein (MAVS), also known as IPS-1, VISA, and Cardif, has
been well studied for its crucial roles in the mammalian interferon immune response. To …

MAVS splicing variants associated with TRAF3 and TRAF6 in NF-κB and IRF3 signaling pathway in large yellow croaker Larimichthys crocea

PF Zou, JC Tang, Y Li, JJ Feng, ZP Zhang… - Developmental & …, 2021 - Elsevier
Mitochondrial antiviral signaling protein (MAVS) acts as an essential adaptor in host RIG-I-
like receptors (RLRs) mediated antiviral signaling pathway. In the present study, two MAVS …

[HTML][HTML] Infectious pancreatic necrosis virus proteins VP2, VP3, VP4 and VP5 antagonize IFNa1 promoter activation while VP1 induces IFNa1

S Lauksund, L Greiner-Tollersrud, CJ Chang… - Virus research, 2015 - Elsevier
Infectious pancreatic necrosis virus (IPNV) is one of the major viral pathogens causing
disease in farmed Atlantic salmon worldwide. In the present work we show that several of …

Molecular characterization and expression analysis of mitochondrial antiviral signaling protein gene in sea perch, Lateolabrax japonicus

P Jia, Y Jin, L Chen, J Zhang, K Jia, M Yi - Developmental & Comparative …, 2016 - Elsevier
The mitochondrial antiviral signaling protein (MAVS) is vital for host defenses against viral
infection by inducing expression of type I interferon. Here, the MAVS of sea perch …

Characterization of a PIAS4 homologue from zebrafish: insights into its conserved negative regulatory mechanism in the TRIF, MAVS, and IFN signaling pathways …

R Xiong, L Nie, L Xiang, J Shao - The Journal of Immunology, 2012 - journals.aai.org
Members of the protein inhibitor of activated STAT (PIAS) family are key regulators of various
human and mammalian signaling pathways, but data on their occurrence and functions in …

MAVS disruption impairs downstream signaling and results in higher virus replication levels of salmonid alphavirus subtype 3 but not infectious pancreatic necrosis …

C Xu, AAA Gamil, X Wang, HM Munang'andu… - Frontiers in …, 2024 - frontiersin.org
The mitochondrial anti-viral signaling (MAVS) protein is an intermediary adaptor protein of
retinoic acid-inducible gene-1 (RIG-I) like receptor (RLR) signaling, which activates the …

Molecular characterization and expression analyses of three RIG-I-like receptor signaling pathway genes (MDA5, LGP2 and MAVS) in Larimichthys crocea

B Shen, Y Hu, S Zhang, J Zheng, L Zeng… - Fish & Shellfish …, 2016 - Elsevier
In this study, we sequenced and characterized melanoma differentiation-associated antigen
5 (LcMDA5), laboratory of genetics and physiology 2 (LcLGP2) and mitochondrial antiviral …

Fish TRIM35 negatively regulates the interferon signaling pathway in response to grouper nodavirus infection

Y Huang, J Zhang, J Liu, Y Hu, S Ni, Y Yang… - Fish & Shellfish …, 2017 - Elsevier
Tripartite motif-containing protein 35 (TRIM35) has been demonstrated to exert critical roles
in cancer, cell death and other multiple cell processes. However, the precisely roles of …

Transcriptome analysis reveals similarities and differences in immune responses in the head and trunk kidneys of yellow catfish (Pelteobagrus fulvidraco) stimulated …

A Zhong, T Gao - Fish & Shellfish Immunology, 2022 - Elsevier
Teleosts have a unique immune system because their head kidney (HK) and trunk kidney
(TK) are sites for hematopoiesis. However, the immune functions of the HK and TKs require …