Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes

DE Leisman, L Ronner, R Pinotti, MD Taylor… - The Lancet …, 2020 - thelancet.com
The description of a so-called cytokine storm in patients with COVID-19 has prompted
consideration of anti-cytokine therapies, particularly interleukin-6 antagonists. However …

[HTML][HTML] Immunopathogenesis and treatment of cytokine storm in COVID-19

JS Kim, JY Lee, JW Yang, KH Lee, M Effenberger… - Theranostics, 2021 - ncbi.nlm.nih.gov
Abstract Severe coronavirus disease 2019 (COVID-19) is characterized by systemic hyper-
inflammation, acute respiratory distress syndrome, and multiple organ failure. Cytokine …

Thrombosis in COVID‐19

TC Hanff, AM Mohareb, J Giri, JB Cohen… - American journal of …, 2020 - Wiley Online Library
Thrombotic complications are frequent in COVID‐19 and contribute significantly to mortality
and morbidity. We review several mechanisms of hypercoagulability in sepsis that may be …

Clinical criteria for COVID-19-associated hyperinflammatory syndrome: a cohort study

BJ Webb, ID Peltan, P Jensen, D Hoda… - The Lancet …, 2020 - thelancet.com
Background A subset of patients with COVID-19 develops a hyperinflammatory syndrome
that has similarities with other hyperinflammatory disorders. However, clinical criteria …

[HTML][HTML] Propolis and its potential against SARS-CoV-2 infection mechanisms and COVID-19 disease: Running title: Propolis against SARS-CoV-2 infection and …

AA Berretta, MAD Silveira, JMC Capcha… - Biomedicine & …, 2020 - Elsevier
Propolis, a resinous material produced by honey bees from plant exudates, has long been
used in traditional herbal medicine and is widely consumed as a health aid and immune …

COVID-19-associated hyperinflammation and escalation of patient care: a retrospective longitudinal cohort study

JJ Manson, C Crooks, M Naja, A Ledlie… - The Lancet …, 2020 - thelancet.com
Background A subset of patients with severe COVID-19 develop a hyperinflammatory
syndrome, which might contribute to morbidity and mortality. This study explores a specific …

COVID-19 severity and mortality in patients with chronic lymphocytic leukemia: a joint study by ERIC, the European Research Initiative on CLL, and CLL Campus

L Scarfò, T Chatzikonstantinou, GM Rigolin… - Leukemia, 2020 - nature.com
Chronic lymphocytic leukemia (CLL) is a disease of the elderly, characterized by
immunodeficiency. Hence, patients with CLL might be considered more susceptible to …

Confronting the controversy: interleukin-6 and the COVID-19 cytokine storm syndrome

LYC Chen, RL Hoiland, S Stukas… - European …, 2020 - Eur Respiratory Soc
The concept of coronavirus disease 2019 (COVID-19)-related cytokine storm syndrome
(COVID-CSS) emerged early in the severe acute respiratory syndrome coronavirus 2 (SARS …

Systemic and organ-specific immune-related manifestations of COVID-19

M Ramos-Casals, P Brito-Zerón… - Nature Reviews …, 2021 - nature.com
Immune-related manifestations are increasingly recognized conditions in patients with
COVID-19, with around 3,000 cases reported worldwide comprising more than 70 different …

The role of NO in COVID-19 and potential therapeutic strategies

W Fang, J Jiang, L Su, T Shu, H Liu, S Lai… - Free radical biology and …, 2021 - Elsevier
Nitric oxide (NO) is a free radical playing an important pathophysiological role in
cardiovascular and immune systems. Recent studies reported that NO levels were …