[HTML][HTML] Aducanumab—hope or disappointment for Alzheimer's disease

K Wojtunik-Kulesza, M Rudkowska… - International journal of …, 2023 - mdpi.com
In June 2021, the world was informed about a new drug for Alzheimer's disease approved
by the FDA. Aducanumab (BIIB037, ADU), being a monoclonal antibody IgG1, is the newest …

[HTML][HTML] Multiple roles of fucoxanthin and astaxanthin against Alzheimer's disease: Their pharmacological potential and therapeutic insights

N Oliyaei, M Moosavi-Nasab, N Tanideh, A Iraji - Brain Research Bulletin, 2023 - Elsevier
Alzheimer's disease (AD) is the most devastating neurodegenerative disorder affecting the
elderly. The exact pathology of AD is not yet fully understood and several hallmarks such as …

A mathematical model analysis of meningitis with treatment and vaccination in fractional derivatives

OJ Peter, A Yusuf, MM Ojo, S Kumar, N Kumari… - International Journal of …, 2022 - Springer
In this paper, we develop a new mathematical model based on the Atangana Baleanu
Caputo (ABC) derivative to investigate meningitis dynamics. We explain why fractional …

[HTML][HTML] Amygdala activity and amygdala-hippocampus connectivity: metabolic diseases, dementia, and neuropsychiatric issues

J Song - Biomedicine & Pharmacotherapy, 2023 - Elsevier
With rapid aging of the population worldwide, the number of people with dementia is
dramatically increasing. Some studies have emphasized that metabolic syndrome, which …

Monoamine oxidase B inhibitors based on natural privileged scaffolds: A review of systematically structural modification

Y Lv, Z Zheng, R Liu, J Guo, C Zhang, Y Xie - International Journal of …, 2023 - Elsevier
Monoamine oxidase is a flavin enzyme that catalyzes the oxidation of monoamine
neurotransmitters in the brain. Various toxic by-products, aldehydes and hydrogen peroxide …

[HTML][HTML] Diet and lifestyle impact the development and progression of Alzheimer's dementia

S Arora, JA Santiago, M Bernstein… - Frontiers in Nutrition, 2023 - frontiersin.org
Dementia is a growing public health concern, with an estimated prevalence of 57 million
adults worldwide. Alzheimer's disease (AD) accounts for 60–80% of the cases. Clinical trials …

Understanding mechanistic aspect of the therapeutic role of herbal agents on neuroplasticity in cerebral ischemic-reperfusion injury

A Bangar, H Khan, A Kaur, K Dua, TG Singh - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Stroke is one of the leading causes of death and disability.
The only FDA-approved therapy for treating stroke is tissue plasminogen activator (tPA) …

[HTML][HTML] Natural alkaloids as multi-target compounds towards factors implicated in Alzheimer's disease

R Vrabec, G Blunden, L Cahlíková - International Journal of Molecular …, 2023 - mdpi.com
Alzheimer's disease (AD) is the most common cause of dementia in elderly people;
currently, there is no efficient treatment. Considering the increase in life expectancy …

[HTML][HTML] The Contribution of the Locus Coeruleus–Noradrenaline System Degeneration during the Progression of Alzheimer's Disease

D Mercan, MT Heneka - Biology, 2022 - mdpi.com
Abstract Alzheimer's disease (AD), which is characterized by extracellular accumulation of
amyloid-beta peptide and intracellular aggregation of hyperphosphorylated tau, is the most …

Machine learning in Alzheimer's disease drug discovery and target identification

C Geng, ZB Wang, Y Tang - Ageing Research Reviews, 2023 - Elsevier
Alzheimer's disease (AD) stands as a formidable neurodegenerative ailment that poses a
substantial threat to the elderly population, with no known curative or disease-slowing drugs …