[HTML][HTML] The future of intensive care: the study of the microcirculation will help to guide our therapies
The goal of hemodynamic resuscitation is to optimize the microcirculation of organs to meet
their oxygen and metabolic needs. Clinicians are currently blind to what is happening in the …
their oxygen and metabolic needs. Clinicians are currently blind to what is happening in the …
[HTML][HTML] Sialylated glycan bindings from SARS-CoV-2 spike protein to blood and endothelial cells govern the severe morbidities of COVID-19
DE Scheim, P Vottero, AD Santin, AG Hirsh - International journal of …, 2023 - mdpi.com
Consistent with well-established biochemical properties of coronaviruses, sialylated glycan
attachments between SARS-CoV-2 spike protein (SP) and host cells are key to the virus's …
attachments between SARS-CoV-2 spike protein (SP) and host cells are key to the virus's …
[HTML][HTML] Oxidative stress-induced endothelial dysfunction and decreased vascular nitric oxide in COVID-19 patients
V Montiel, I Lobysheva, L Gerard, M Vermeersch… - …, 2022 - thelancet.com
Background SARS-CoV-2 targets endothelial cells through the angiotensin-converting
enzyme 2 receptor. The resulting endothelial injury induces widespread thrombosis and …
enzyme 2 receptor. The resulting endothelial injury induces widespread thrombosis and …
Right ventricular dysfunction and its association with mortality in coronavirus disease 2019 acute respiratory distress syndrome
OBJECTIVES: To assess whether right ventricular dilation or systolic impairment is
associated with mortality and/or disease severity in invasively ventilated patients with …
associated with mortality and/or disease severity in invasively ventilated patients with …
[HTML][HTML] Multiplatform analyses reveal distinct drivers of systemic pathogenesis in adult versus pediatric severe acute COVID-19
S Druzak, E Iffrig, BR Roberts, T Zhang… - Nature …, 2023 - nature.com
The pathogenesis of multi-organ dysfunction associated with severe acute SARS-CoV-2
infection remains poorly understood. Endothelial damage and microvascular thrombosis …
infection remains poorly understood. Endothelial damage and microvascular thrombosis …
Machine learning using the extreme gradient boosting (XGBoost) algorithm predicts 5-day delta of SOFA score at ICU admission in COVID-19 patients
Background: Accurate risk stratification of critically ill patients with coronavirus disease 2019
(COVID-19) is essential for optimizing resource allocation, delivering targeted interventions …
(COVID-19) is essential for optimizing resource allocation, delivering targeted interventions …
[HTML][HTML] Assessment of blood microcirculation changes after COVID-19 using wearable laser Doppler flowmetry
EV Zharkikh, YI Loktionova, AA Fedorovich… - Diagnostics, 2023 - mdpi.com
The present work is focused on the study of changes in microcirculation parameters in
patients who have undergone COVID-19 by means of wearable laser Doppler flowmetry …
patients who have undergone COVID-19 by means of wearable laser Doppler flowmetry …
[HTML][HTML] Red blood cell shape and deformability in patients with COVID-19 acute respiratory distress syndrome
M Piagnerelli, J Vanderelst, A Rousseau… - Frontiers in …, 2022 - frontiersin.org
Background Acute respiratory distress syndrome due to coronavirus disease 2019 (COVID-
19) is associated with high mortality. Several studies have reported that the microcirculation …
19) is associated with high mortality. Several studies have reported that the microcirculation …
[HTML][HTML] Microcirculation-guided resuscitation in sepsis: the next frontier?
E Damiani, A Carsetti, E Casarotta, R Domizi… - Frontiers in …, 2023 - frontiersin.org
Microcirculatory dysfunction plays a key role in the pathogenesis of tissue dysoxia and
organ failure in sepsis. Sublingual videomicroscopy techniques enable the real-time non …
organ failure in sepsis. Sublingual videomicroscopy techniques enable the real-time non …
Nailfold capillaroscopy: a sensitive method for evaluating microvascular involvement in children with SARS-CoV-2 infection
Objectives The hyperinflammatory state and the viral invasion may result in endothelial
dysfunction in SARS-CoV-2 infection. Although a method foreseeing microvascular …
dysfunction in SARS-CoV-2 infection. Although a method foreseeing microvascular …