Plasmodium sporozoite transmission is a critical population bottleneck in parasite life-cycle
progression and, hence, a target for prophylactic drugs and vaccines. The recent progress of …

Globally, parasites are increasingly being recognized as catastrophic agents in both
aquaculture sector and in the wild aquatic habitats leading to an estimated annual loss …

Sexual differentiation of malaria parasites into gametocytes in the vertebrate host and
subsequent gamete fertilization in mosquitoes is essential for the spreading of the disease …

Immunization with attenuated Plasmodium falciparum sporozoites (PfSPZs) has been shown
to be protective against malaria, but the features of the antibody response induced by this …

Plasmodium sporozoites are transmitted from infected mosquitoes to mammals, and must
navigate the host skin and vasculature to infect the liver. This journey requires distinct …

Malaria parasite infection is initiated by the mosquito-transmitted sporozoite stage, a highly
motile invasive cell that targets hepatocytes in the liver for infection. A promising approach to …

Obligate intracellular parasites must efficiently invade host cells in order to mature and be
transmitted. For the malaria parasite Plasmodium falciparum, invasion of host red blood cells …

Functional analysis of essential genes in the malarial parasite, Plasmodium, is hindered by
lack of efficient strategies for conditional protein regulation. We report the development of a …

Plasmodium sporozoites that are transmitted by blood-feeding female Anopheles
mosquitoes invade hepatocytes for an initial round of intracellular replication, leading to the …

Plasmodium falciparum and Plasmodium vivax cause the majority of human malaria cases.
Research efforts predominantly focus on P. falciparum because of the clinical severity of …