[HTML][HTML] Ischemia reperfusion injury—a translational perspective in organ transplantation

AR Fernández, R Sánchez-Tarjuelo, P Cravedi… - International journal of …, 2020 - mdpi.com
Thanks to the development of new, more potent and selective immunosuppressive drugs
together with advances in surgical techniques, organ transplantation has emerged from an …

Hypothermic machine perfusion in liver transplantation—a randomized trial

R van Rijn, IJ Schurink, Y de Vries… - … England Journal of …, 2021 - Mass Medical Soc
Background Transplantation of livers obtained from donors after circulatory death is
associated with an increased risk of nonanastomotic biliary strictures. Hypothermic …

A contemporary systematic review on liver transplantation for unresectable liver metastases of colorectal cancer

CM Lebeck Lee, IA Ziogas, R Agarwal… - Cancer, 2022 - Wiley Online Library
The 5‐year overall survival rate of a patient with unresectable metastatic colorectal cancer is
poor at approximately 14%. Similarly, historical data on liver transplantation (LT) in those …

[HTML][HTML] Liver transplantation outcomes from controlled circulatory death donors: SCS vs in situ NRP vs ex situ NMP

R Gaurav, AJ Butler, V Kosmoliaptsis… - Annals of …, 2022 - journals.lww.com
Objective: To compare the outcomes of livers donated after circulatory death (DCD) and
undergoing either in situ normothermic regional perfusion (NRP) or ex situ normothermic …

[HTML][HTML] Expanding controlled donation after the circulatory determination of death: statement from an international collaborative

B Domínguez-Gil, N Ascher, AM Capron… - Intensive care …, 2021 - Springer
A decision to withdraw life-sustaining treatment (WLST) is derived by a conclusion that
further treatment will not enable a patient to survive or will not produce a functional outcome …

Normothermic regional perfusion vs. super-rapid recovery in controlled donation after circulatory death liver transplantation

AJ Hessheimer, E Coll, F Torres, P Ruíz, M Gastaca… - Journal of …, 2019 - Elsevier
Background & Aims Although there is increasing interest in its use, definitive evidence
demonstrating a benefit for postmortem normothermic regional perfusion (NRP) in controlled …

Outcomes of DCD liver transplantation using organs treated by hypothermic oxygenated perfusion before implantation

A Schlegel, X Muller, M Kalisvaart, B Muellhaupt… - Journal of …, 2019 - Elsevier
Background & Aims Donation after circulatory death (DCD) liver transplantation is known for
potentially worse outcomes because of higher rates of graft non-function or irreversible …

Transplantation of high-risk donor livers after ex situ resuscitation and assessment using combined hypo-and normothermic machine perfusion: a prospective clinical …

OB van Leeuwen, Y de Vries, M Fujiyoshi… - Annals of …, 2019 - journals.lww.com
Objective: The aim of this study was to evaluate sequential hypothermic and normothermic
machine perfusion (NMP) as a tool to resuscitate and assess viability of initially declined …

Sequential hypothermic and normothermic machine perfusion enables safe transplantation of high‐risk donor livers

OB van Leeuwen, SB Bodewes… - American Journal of …, 2022 - Wiley Online Library
Ex situ normothermic machine perfusion (NMP) is increasingly used for viability assessment
of high‐risk donor livers, whereas dual hypothermic oxygenated machine perfusion …

First comparison of hypothermic oxygenated perfusion versus static cold storage of human donation after cardiac death liver transplants: an international-matched …

P Dutkowski, WG Polak, P Muiesan, A Schlegel… - Annals of …, 2015 - journals.lww.com
Background: Exposure of donor liver grafts to prolonged periods of warm ischemia before
procurement causes injuries including intrahepatic cholangiopathy, which may lead to graft …