Recent advances in exosome-mediated nucleic acid delivery for cancer therapy

Y Zhang, Q Liu, X Zhang, H Huang, S Tang… - Journal of …, 2022 - Springer
Cancer is a leading public health problem worldwide. Its treatment remains a daunting
challenge, although significant progress has been made in existing treatments in recent …

Roles and mechanisms of exosomal non-coding RNAs in human health and diseases

C Li, YQ Ni, H Xu, QY Xiang, Y Zhao, JK Zhan… - Signal transduction and …, 2021 - nature.com
Exosomes play a role as mediators of cell-to-cell communication, thus exhibiting pleiotropic
activities to homeostasis regulation. Exosomal non-coding RNAs (ncRNAs), mainly …

Application of exosomes as liquid biopsy in clinical diagnosis

B Zhou, K Xu, X Zheng, T Chen, J Wang… - Signal transduction and …, 2020 - nature.com
Liquid biopsy refers to the sampling and molecular analysis of the biofluids of circulating
tumor cells, extracellular vesicles, nucleic acids, and so forth. Exosomes are small …

EMT‐associated microRNAs and their roles in cancer stemness and drug resistance

G Pan, Y Liu, L Shang, F Zhou… - Cancer …, 2021 - Wiley Online Library
Epithelial‐to‐mesenchymal transition (EMT) is implicated in a wide array of malignant
behaviors of cancers, including proliferation, invasion, and metastasis. Most notably, previou …

Cancer drug resistance induced by EMT: novel therapeutic strategies

J De Las Rivas, A Brozovic, S Izraely, A Casas-Pais… - Archives of …, 2021 - Springer
Over the last decade, important clinical benefits have been achieved in cancer patients by
using drug-targeting strategies. Nevertheless, drug resistance is still a major problem in …

Hypoxic glioma-derived exosomes deliver microRNA-1246 to induce M2 macrophage polarization by targeting TERF2IP via the STAT3 and NF-κB pathways

M Qian, S Wang, X Guo, J Wang, Z Zhang, W Qiu… - Oncogene, 2020 - nature.com
Exosomes are emerging as important elements that participate in intercellular
communication and tumor microenvironment modulation, but the exact mechanisms by …

Colorectal cancer‐derived small extracellular vesicles promote tumor immune evasion by upregulating PD‐L1 expression in tumor‐associated macrophages

Y Yin, B Liu, Y Cao, S Yao, Y Liu, G Jin, Y Qin… - Advanced …, 2022 - Wiley Online Library
Tumor‐associated macrophages (TAMs) are one of the most abundant cell types in
colorectal cancer (CRC) tumor microenvironment (TME). Recent studies observed …

Hypoxic glioma-derived exosomes promote M2-like macrophage polarization by enhancing autophagy induction

J Xu, J Zhang, Z Zhang, Z Gao, Y Qi, W Qiu, Z Pan… - Cell Death & …, 2021 - nature.com
Exosomes participate in intercellular communication and glioma microenvironment
modulation, but the exact mechanisms by which glioma-derived exosomes (GDEs) promote …

Extracellular vesicles and particles impact the systemic landscape of cancer

S Lucotti, CM Kenific, H Zhang, D Lyden - The EMBO journal, 2022 - embopress.org
Intercellular cross talk between cancer cells and stromal and immune cells is essential for
tumor progression and metastasis. Extracellular vesicles and particles (EVPs) are a …

Expression, regulation, and function of exosome‐derived miRNAs in cancer progression and therapy

B Li, Y Cao, M Sun, H Feng - The FASEB Journal, 2021 - Wiley Online Library
Exosomes are a novel class of intercellular signal modulators that contain a wide range of
molecules and deliver information between cells and tissues. MicroRNAs (miRNAs), a type …