Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths in
the world. Metabolic reprogramming is considered a new hallmark of cancer, but it remains …

T cell immunoreceptor with Ig and ITIM domains (TIGIT) is an inhibitory receptor expressed
on several types of lymphocytes. Efficacy of antibody blockade of TIGIT in cancer …

Liver metastasis, the leading cause of colorectal cancer mortality, exhibits a highly
heterogeneous and suppressive immune microenvironment. Here, we sequenced 97 …

Abstract Background Circular RNAs (circRNAs) can be encapsulated into exosomes to
participate in intercellular communication, affecting the malignant progression of a variety of …

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide,
and therapeutic options for advanced HCC are limited. Here, we observe that intestinal …

Background T cells form the major component of anti-tumor immunity. A deeper
understanding of T cell exhaustion (TEX) heterogeneity within the tumor microenvironment …

Intrahepatic cholangiocarcinoma (iCCA) is a highly heterogeneous cancer with limited
understanding of its classification and tumor microenvironment. Here, by performing single …

More than 90% of cases of hepatocellular carcinoma (HCC) occurs in patients with cirrhosis,
of which hepatitis B virus and hepatitis C virus are the leading causes, while the tumor less …

Background & Aims Despite recent translation of immunotherapies into clinical practice, the
immunobiology of hepatocellular carcinoma (HCC), in particular the role and clinical …

Immune associated cells in the microenvironment have a significant impact on the
development and progression of hepatocellular carcinoma (HCC) and have received more …