[HTML][HTML] How to slow down the ticking clock: age-associated epigenetic alterations and related interventions to extend life span
Epigenetic alterations pose one major hallmark of organismal aging. Here, we provide an
overview on recent findings describing the epigenetic changes that arise during aging and …
overview on recent findings describing the epigenetic changes that arise during aging and …
Biological clocks as age estimation markers in animals: a systematic review and meta‐analysis
LS Le Clercq, A Kotzé, JP Grobler… - Biological …, 2023 - Wiley Online Library
Various biological attributes associated with individual fitness in animals change predictably
over the lifespan of an organism. Therefore, the study of animal ecology and the work of …
over the lifespan of an organism. Therefore, the study of animal ecology and the work of …
The naked mole-rat as a model for healthy aging
Naked mole-rats (NMRs, Heterocephalus glaber) are the longest-lived rodents with a
maximum life span exceeding 37 years. They exhibit a delayed aging phenotype and …
maximum life span exceeding 37 years. They exhibit a delayed aging phenotype and …
Characterization of naked mole‐rat hematopoiesis reveals unique stem and progenitor cell patterns and neotenic traits
S Emmrich, A Trapp, F Tolibzoda Zakusilo… - The EMBO …, 2022 - embopress.org
Naked mole rats (NMRs) are the longest‐lived rodents yet their stem cell characteristics
remain enigmatic. Here, we comprehensively mapped the NMR hematopoietic landscape …
remain enigmatic. Here, we comprehensively mapped the NMR hematopoietic landscape …
[HTML][HTML] Harnessing male germline epigenomics for the genetic improvement in cattle
Sperm is essential for successful artificial insemination in dairy cattle, and its quality can be
influenced by both epigenetic modification and epigenetic inheritance. The bovine germline …
influenced by both epigenetic modification and epigenetic inheritance. The bovine germline …
[HTML][HTML] Biomarkers of aging
Aging Biomarker Consortium, H Bao, J Cao… - Science China Life …, 2023 - Springer
Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …
[HTML][HTML] DNA methylation entropy as a measure of stem cell replication and aging
Background Epigenetic marks are encoded by DNA methylation and accumulate errors as
organisms age. This drift correlates with lifespan, but the biology of how this occurs is still …
organisms age. This drift correlates with lifespan, but the biology of how this occurs is still …
[HTML][HTML] DNA methylation profile in beef cattle is influenced by additive genetics and age
AMF Ribeiro, LP Sanglard, HR Wijesena… - Scientific reports, 2022 - nature.com
DNA methylation (DNAm) has been considered a promising indicator of biological age in
mammals and could be useful to increase the accuracy of phenotypic prediction in livestock …
mammals and could be useful to increase the accuracy of phenotypic prediction in livestock …
Emerging epigenetic insights into aging mechanisms and interventions
Epigenetic dysregulation emerges as a critical hallmark and driving force of aging. Although
still an evolving field with much to explore, it has rapidly gained significance by providing …
still an evolving field with much to explore, it has rapidly gained significance by providing …
[PDF][PDF] A hyper-quiescent chromatin state formed during aging is reversed by regeneration
Epigenetic alterations are a key hallmark of aging but have been limitedly explored in
tissues. Here, using naturally aged murine liver as a model and extending to other quiescent …
tissues. Here, using naturally aged murine liver as a model and extending to other quiescent …