The arginase enzyme developed in early life forms and was maintained during evolution. As
the last step in the urea cycle, arginase cleaves l-arginine to form urea and l-ornithine. The …

Arginase has roots in early life-forms. It converts L-arginine to urea and ornithine. The former
provides protection against NH 3; the latter serves to stimulate cell growth and other …

Background: Endothelial dysfunction has a key role in the pathogenesis of coronavirus
disease 2019 (COVID-19) and its disabling complications. We designed a case-control …

Under physiological conditions, perivascular adipose tissue (PVAT) attenuates agonist‐
induced vasoconstriction by releasing vasoactive molecules including hydrogen peroxide …

Diabetes alters microvascular function in the vascular beds of organs, including the lungs.
Cardiovascular complications of pulmonary vascular affectation may be a consequence of …

Objective—The present study was conducted to investigate the contribution of perivascular
adipose tissue (PVAT) to vascular dysfunction in a mouse model of diet-induced obesity …

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the virus responsible
for the COVID-19 pandemic. Patients may present as asymptomatic or demonstrate mild to …

Genetic variants at the solute carrier family 39 member 8 (SLC39A8) gene locus are
associated with the regulation of whole-blood manganese (Mn) and multiple physiological …

Abstract Angiotensin converting enzyme-2 (ACE2) is a multifunctional transmembrane
protein recently recognised as the entry receptor of the virus causing COVID-19. In the renin …

There is an ongoing threat of epidemic or pandemic diseases that could be caused by
influenza, Ebola or other emerging viruses. It will be difficult and costly to develop new drugs …