Histone H3K27me3 demethylase KDM6B (also known as Jumonji domain-containing
protein D3, JMJD3) plays vital roles in the etiology of inflammatory responses; however, little …

Histones are subjected to extensive covalent modifications that affect inter-nucleosomal
interactions as well as alter chromatin structure and DNA accessibility. Through switching …

Background Several studies have established a positive relationship between sleep
difficulties and symptomatology in ASD children. The rationale for this review is to describe …

Apart from the conventional view of repressive promoter methylation, the DNA
methyltransferase 1 (DNMT1) was recently described to modulate gene expression through …

With the aging population growing and the incidence of neurodegenerative diseases on the
rise, the researchers in the field are yet more urgently challenged to slow and/or reverse the …

Chronic exposure to stress throughout lifespan alters brain structure and function, inducing a
maladaptive response to environmental stimuli, that can contribute to the development of a …

Despite an increasing amount of research on work-related stress and burnout, our
knowledge on the underlying biological mechanisms remains scarce. So far, biomarkers of …

Background Seasonal variations in environmental exposures at birth or during gestation are
associated with numerous adult traits and health outcomes later in life. Whether DNA …

Abstract Sirtuin 6 (SIRT6), a member of the Sirtuin family, acts as nicotinamide adenine
dinucleotide (NAD)-dependent protein deacetylase, mono-adenosine diphosphate (ADP) …

Genetics and epigenetics of stress involves the genetic and geneticby-environmental factors
that influence the effects of stress on mental health and disease. The study of the genetics …