In recent years, with the rapid development of techniques in bioinformatics and life science,
a considerable quantity of biomedical data has been accumulated, based on which …

Pharmacogenomics is a study of how the genome background is associated with drug
resistance and how therapy strategy can be modified for a certain person to achieve benefit …

β-glucuronidases (GUS) of intestinal bacteria remove glucuronic acid from glucoronides,
reversing phase II metabolism of the liver and affecting the level of active deconjugated …

Many diseases and health conditions are closely related to various microbes, which
participate in complex interactions with diverse drugs; nonetheless, the detailed targets of …

Precision medicine gives individuals tailored medical treatment, with the genotype
determining the therapeutic strategy, the appropriate dosage, and the likelihood of benefit or …

Individual variability in drug response (IVDR) can be a major cause of adverse drug
reactions (ADRs) and prolonged therapy, resulting in a substantial health and economic …

About 80% of brain disorders have a genetic basis. The pathogenesis of most
neurodegenerative diseases is associated with a myriad of genetic defects, epigenetic …

Type 2 diabetes mellitus (T2DM), a major driver of mortality worldwide, is more likely to
develop other cardiometabolic risk factors, ultimately leading to diabetes-related mortality …

Background Intestinal microbiota has been confirmed to influencing the pharmacokinetic
processes of a variety of oral drugs. However, the pharmacokinetic effects of the gut …

Cardiovascular diseases (CVDs), the most common cause of mortality in rich countries,
include a wide variety of pathologies of the heart muscle and vascular system that …