[HTML][HTML] Phytochemicals for the prevention and treatment of renal cell carcinoma: preclinical and clinical evidence and molecular mechanisms

EM Bajalia, FB Azzouz, DA Chism, DM Giansiracusa… - Cancers, 2022 - mdpi.com
Simple Summary Renal cell carcinoma (RCC) is the most frequently diagnosed kidney
cancer. Once RCC metastasizes, successful treatment is difficult to achieve. There is an …

The Cross‐Talk between Polyphenols and the Target Enzymes Related to Oxidative Stress‐Induced Thyroid Cancer

S Heydarzadeh, SK Kia, M Zarkesh… - Oxidative Medicine …, 2022 - Wiley Online Library
The most serious hallmark step of carcinogenesis is oxidative stress, which induces cell
DNA damage. Although in normal conditions ROS are important second messengers, in …

[HTML][HTML] Genistein, a tool for geroscience

C Mas-Bargues, C Borras, J Vina - Mechanisms of Ageing and …, 2022 - Elsevier
Geroprotection is defined as protection from the adverse effects of aging. The need for
geroprotection implies changes towards individually tailored interventions that preserve an …

Improving the genistein oral bioavailability via its formulation into the metal–organic framework MIL-100 (Fe)

A Botet-Carreras, C Tamames-Tabar… - Journal of Materials …, 2021 - pubs.rsc.org
Despite the interesting chemopreventive, antioxidant and antiangiogenic effects of the
natural bioflavonoid genistein (GEN), its low aqueous solubility and bioavailability make it …

Potential roles of natural products in the targeting of proteinopathic neurodegenerative diseases

R Dash, I Jahan, MC Ali, S Mitra, YA Munni… - Neurochemistry …, 2021 - Elsevier
Defective proteostasis is associated with the gradual accumulations of misfolded proteins
and is a hallmark of many age-associated neurodegenerative diseases. In the aged brain …

Anti-inflammatory effects of different dietary antioxidants

A Roy, S Das, I Chatterjee, S Roy… - Plant Antioxidants and …, 2022 - Springer
Chronic inflammation and oxidative damage have been proven as fundamental factors
associated with many systemic diseases, leading to increased morbidity. To deal with this …

Multifunctional Tumor-Targeting Carbon Dots for Tumor Microenvironment Activated Ferroptosis and Immunotherapy in Cancer Treatment

Y Bao, G Li, S Li, H Zhang, X Wu, R Yan… - … Applied Materials & …, 2023 - ACS Publications
As an emerging cancer treatment strategy, ferroptosis is distinguished by the perturbation of
lipid metabolism equilibrium and the accumulation of lipid peroxidation. However, the …

[HTML][HTML] Estrogen receptor beta: the promising biomarker and potential target in metastases

A Božović, V Mandušić, L Todorović… - International Journal of …, 2021 - mdpi.com
The discovery of the Estrogen Receptor Beta (ERβ) in 1996 opened new perspectives in the
diagnostics and therapy of different types of cancer. Here, we present a review of the present …

[HTML][HTML] Antioxidant potential and cytotoxic effect of isoflavones extract from Thai fermented soybean (Thua-Nao)

K Kulprachakarn, S Chaipoot, R Phongphisutthinant… - Molecules, 2021 - mdpi.com
Thua-nao, or Thai fermented soybeans, is a traditional Lanna fermented food in Northern
Thailand. It is produced by using a specific bacterial species called Bacillus subtilis var …

[HTML][HTML] Dietary phytoestrogens and their metabolites as epigenetic modulators with impact on human health

VS Ionescu, A Popa, A Alexandru, E Manole, M Neagu… - Antioxidants, 2021 - mdpi.com
The impact of dietary phytoestrogens on human health has been a topic of continuous
debate since their discovery. Nowadays, based on their presumptive beneficial effects, the …