[HTML][HTML] Pleiotropic effects of isoflavones in inflammation and chronic degenerative diseases

J Bernatoniene, JA Kazlauskaite… - International Journal of …, 2021 - mdpi.com
Isoflavones are phytoestrogens of plant origin, mostly found in the members of the Fabaceae
family, that exert beneficial effects in various degenerative disorders. Having high similarity …

Modulation of hypoxia-inducible factor-1 signaling pathways in cancer angiogenesis, invasion, and metastasis by natural compounds: a comprehensive and critical …

S Fakhri, SZ Moradi, F Faraji, L Kooshki… - Cancer and Metastasis …, 2024 - Springer
Tumor cells employ multiple signaling mediators to escape the hypoxic condition and trigger
angiogenesis and metastasis. As a critical orchestrate of tumorigenic conditions, hypoxia …

Role of plant-derived flavonoids in cancer treatment

P Tiwari, KP Mishra - Nutrition and cancer, 2023 - Taylor & Francis
Flavonoids are polyphenolic phytochemicals, which occur naturally in plants and possess
both anti-oxidant and pro-oxidant properties. Flavonoids are gaining increasing popularity in …

[HTML][HTML] Synthesis and chemopreventive potential of 5-fu/genistein hybrids on colorectal cancer cells

G Moreno-Quintero, W Castrillón-Lopez… - Pharmaceuticals, 2022 - mdpi.com
A series of 5-FU-Genistein hybrids were synthesized and their structures were elucidated by
spectroscopic analysis. The chemopreventive potential of these compounds was evaluated …

Effect of genistein intake on some cardiovascular risk factors: an updated systematic review and meta-analysis

A Amerizadeh, S Asgary, G Vaseghi… - Current problems in …, 2022 - Elsevier
Genistein, an isoflavone in soybean products has potential cardio-protective effects and is
used also as an alternative for estrogen therapy in postmenopausal women. However …

[HTML][HTML] Lunasin as a promising plant-derived peptide for cancer therapy

SM Alves de Souza, B Hernández-Ledesma… - International Journal of …, 2022 - mdpi.com
Cancer has become one of the main public health problems worldwide, demanding the
development of new therapeutic agents that can help reduce mortality. Lunasin is a soybean …

[HTML][HTML] Understanding lung carcinogenesis from a morphostatic perspective: Prevention and therapeutic potential of phytochemicals for targeting cancer stem cells

WS Heng, FAE Kruyt, SC Cheah - International journal of molecular …, 2021 - mdpi.com
Lung cancer is still one of the deadliest cancers, with over two million incidences annually.
Prevention is regarded as the most efficient way to reduce both the incidence and death …

[HTML][HTML] Regenerative wound dressings for skin cancer

TI Pavel, C Chircov, M Rădulescu, AM Grumezescu - Cancers, 2020 - mdpi.com
Simple Summary As the currently and commonly applied treatment strategies for skin cancer
are highly invasive and possibly disfiguring, new approaches should focus on developing …

Estrogen receptors as potential therapeutic target in endometrial cancer

P Guha, K Sen, P Chowdhury… - Journal of Receptors and …, 2023 - Taylor & Francis
Endometrial cancer (EC) is one of the most common gynecological carcinomas in both
developed and developing countries. Majority of the gynecological malignancies are …

[HTML][HTML] Therapeutic potential and mechanisms of novel simple o-substituted isoflavones against cerebral ischemia reperfusion

SE Yang, JC Lien, CW Tsai, CR Wu - International Journal of Molecular …, 2022 - mdpi.com
Isoflavones have been widely studied and have attracted extensive attention in fields
ranging from chemotaxonomy and plant physiology to human nutrition and medicine …