Background Epidemiologic studies, including trials, suggest an association between
potassium intake and blood pressure (BP). However, the strength and shape of this …

Background: Type 2 diabetes mellitus is a complex progressive endocrine disease
characterized by hyperglycemia and life-threatening complications. It is the most common …

Parkinson's disease (PD) is a common neurodegenerative disorder that primarily affects the
elderly. While the etiology of PD is likely multifactorial with the involvement of genetic …

Pericytes have been implicated in various neuropathologies, yet little is known about their
function and signaling pathways in health. Here, we characterized calcium dynamics of …

Cardiovascular diseases are the leading cause of death worldwide. The long-term aim of
cardiovascular disease therapy is to reduce the mortality rate and decelerate the …

Migraine is a debilitating neurological condition affecting millions of people worldwide. Until
a few years ago, preventive migraine treatments were based on molecules with pleiotropic …

Mitochondrial potassium channels have been described as important factors in cell pro-life
and death phenomena. The activation of mitochondrial potassium channels, such as ATP …

Transient receptor potential cation channels subfamily V member 4 (TRPV4) are non-
selective cation channels expressed in different cell types of the central nervous system …

The field of mitochondrial ion channels underwent a rapid development during the last
decade, thanks to the molecular identification of some of the nuclear-encoded organelle …

Vascular tone is dependent on smooth muscle KATP channels comprising pore-forming
Kir6. 1 and regulatory SUR2B subunits, in which mutations cause Cantú syndrome. Unique …