[HTML][HTML] The role of TAPSE/sPAP ratio in predicting pulmonary hypertension and mortality in the systemic sclerosis EUSTAR cohort

A Colalillo, AM Hoffmann-Vold, C Pellicano… - Autoimmunity …, 2023 - Elsevier
Objectives The study aim was to evaluate the predictive role of the echocardiography-
derived tricuspid annular plane systolic excursion/systolic pulmonary artery pressure …

Genetic counselling and testing in pulmonary arterial hypertension: a consensus statement on behalf of the International Consortium for Genetic Studies in PAH

CA Eichstaedt, C Belge, WK Chung… - European …, 2023 - Eur Respiratory Soc
Pulmonary arterial hypertension (PAH) is a rare disease that can be caused by (likely)
pathogenic germline genomic variants. In addition to the most prevalent disease gene …

Concomitant latent pulmonary vascular disease leads to impaired global cardiac performance in heart failure with preserved ejection fraction

A Schuster, A Schulz, T Lange, R Evertz… - European Journal of …, 2023 - Wiley Online Library
ABSTRACT Aims The REDUCE‐LAP II trial demonstrated adverse outcomes after interatrial
shunt device (IASD) placement in heart failure with preserved ejection fraction (HFpEF) …

Tricuspid valve academic research consortium definitions for tricuspid regurgitation and trial endpoints

RT Hahn, MK Lawlor, CJ Davidson… - European heart …, 2023 - academic.oup.com
Interest in the pathophysiology, etiology, management, and outcomes of patients with
tricuspid regurgitation (TR) has grown in the wake of multiple natural history studies showing …

Molecular regulation and therapeutic implications of cell death in pulmonary hypertension

E Wang, S Zhou, D Zeng, R Wang - Cell Death Discovery, 2023 - nature.com
Pulmonary hypertension (PH) is a clinical and pathophysiological syndrome caused by
changes in pulmonary vascular structure or function that results in increased pulmonary …

Pulmonary hypertension: a contemporary review

S Johnson, N Sommer, K Cox-Flaherty… - American Journal of …, 2023 - atsjournals.org
Major advances in pulmonary arterial hypertension, pulmonary hypertension (PH)
associated with lung disease, and chronic thromboembolic PH cast new light on the …

Targeting Mitochondrial Metabolic Dysfunction in Pulmonary Hypertension: Toward New Therapeutic Approaches?

M Riou, I Enache, F Sauer, AL Charles… - International journal of …, 2023 - mdpi.com
Pulmonary arterial hypertension (PAH) is a rare disease characterized by pulmonary
vascular remodeling leading to right heart failure and death. To date, despite the three …

Pathogenesis, clinical features, and phenotypes of pulmonary hypertension associated with interstitial lung disease: A consensus statement from the Pulmonary …

L Piccari, B Allwood, K Antoniou, JH Chung… - Pulmonary …, 2023 - Wiley Online Library
Pulmonary hypertension (PH) is a frequent complication of interstitial lung disease (ILD).
Although PH has mostly been described in idiopathic pulmonary fibrosis, it can manifest in …

STAT3 as a therapeutic target in the metformin-related treatment

W Zhang, D Li, B Li, X Chu, B Kong - International Immunopharmacology, 2023 - Elsevier
Signal transducers and activators of transcription 3 (STAT3) signaling plays an important
role in mediating tumor progression, inflammation, cardiovascular disease, and other …

Iron deficiency in pulmonary vascular disease: pathophysiological and clinical implications

P Martens, S Yu, B Larive, BA Borlaug… - European heart …, 2023 - academic.oup.com
Aims Iron deficiency is common in pulmonary hypertension, but its clinical significance and
optimal definition remain unclear. Methods and results Phenotypic data for 1028 patients …