The human nature of curiosity, wonder, and ingenuity date back to the age of humankind. In
parallel with our history of civilization, interest in scientific approaches to unravel …

Chalcone derivatives are considered valuable species because they possess a
ketoethylenic moiety, CO–CH═ CH–. Due to the presence of a reactive α, β-unsaturated …

Tetrazole derivatives are a prime class of heterocycles, very important to medicinal
chemistry and drug design due to not only their bioisosterism to carboxylic acid and amide …

Privileged structures have been widely used as an effective template in medicinal chemistry
for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring …

Medicinal chemists continue to be fascinated by chalcone derivatives because of their
simple chemistry, ease of hydrogen atom manipulation, straightforward synthesis, and a …

Chalcones, containing an α, β-unsaturated ketone fragment, are an important
pharmacologically active agents because of their diverse mechanisms. This review provides …

Chalcones belong to the flavonoid class of phenolic compounds. They form one of the
largest groups of bioactive natural products. The potential anticancer, anti-inflammatory …

α, β-Unsaturated chalcone moieties and quinoline scaffolds play an important role in
medicinal chemistry, especially in the identification and development of potential anticancer …

Some viral outbreaks have plagued the world since antiquity, including the most recent
COVID-19 pandemic. The continuous spread and emergence of new viral diseases have …

Chalcone or (E)-1, 3-diphenyl-2-propene-1-one scaffold has gained considerable scientific
interest in medicinal chemistry owing to its simple chemistry, ease in synthesizing a variety …