The potential of natural and synthetic chalcones as therapeutic leads against different
pathological conditions has been investigated for several years, and this class of …

In an attempt to develop potent and selective anticancer agents, a series of 15 conjugates of
1, 4-dihydroindeno [1, 2-c] pyrazole chalcone (12a-o) were designed, synthesized and …

The p53 protein is one of the most important tumor suppressors that are frequently
inactivated in cancer cells. This inactivation occurs either because the TP53 gene is mutated …

Owing to ever-increasing bacterial and fungal drug resistance, we attempted to develop
novel antitubercular and antimicrobial agents. For this purpose, we developed some new …

A series of pyrazolo [1, 5-a] pyrimidines substituted at C5 with 1-phenylprop-2-en-1-one (6a–
q) and 3-phenylprop-2-en-1-one (7a–k) was synthesized and evaluated for antiproliferative …

A series of novel difluoromethylpyrazole carboxamides derivatives were synthesized by
introduction of flexible alkyl chain. Nematicidal bioassay results showed that some of them …

Although a diverse range of chemical entities offering striking therapeutic potential against
urease enzyme has been reported, the key challenges (toxicity and safety) associated with …

Background Sepsis is a debilitating systemic disease and described as a severe and
irregular systemic inflammatory reaction syndrome (SIRS) against infection. We employed …

The development of chalcone-based compounds for CNS disorders has been explored by
many research groups. Chalcones are being considered as a potent organic scaffold with …

Licochalcone B (Lico B), which is normally isolated from the roots of Glycyrrhiza inflata
(Chinese Licorice), generally classified into organic compounds including retrochalcones …