Tumor suppressor protein p53 induces cell cycle arrest and apoptotic cell death in response
to various cellular stresses thereby preventing cancer development. Activation and …

Abstract Licochalcone B (Lico B), which belongs to the retrochalcone family, is isolated from
the roots of Chinese licorice. Lico B has been reported to have several other useful …

We previously reported that chalcone CM-M345 (1) and diarylpentanoid BP-C4 (2) induced
p53-dependent growth inhibitory activity in human cancer cells. Herein, CM-M345 (1) and …

Chalcones, ie, compounds with the chemical pattern of 1, 3-diphenylprop-2-en-1-ones, exert
a wide range of bio-activities, eg, antioxidant, anti-inflammatory, anticancer, anti-infective …

Chalcone is a molecule with known biological activities. Based on this, a series of chalcone
derivatives bearing methyl, phenyl or furanyl substituents at different positions of A and B …

Computer-Aided Drug Design (CADD) techniques have garnered a great deal of attention in
academia and industry because of their great versatility, low costs, possibilities of cost …

Continued emerging resistance of pathogens against the clinically approved candidates and
their associated limitations continuously demand newer agents having better potency with a …

Candida albicans and Staphylococcus aureus are common human pathogens, frequently
isolated independently or co-isolated from bloodstream infections, and able to form dense …

With an intention of identifying chalcone derivatives exhibiting anti-protozoal activity, a
cohort of relatively unexplored arylpyrrole-based chalcone derivatives were synthesized in …

Chalcone derivatives are simple chemical scaffold found in natural products and have been
extensively used as an effective template in medicinal chemistry for drug discovery. Two …