Severe cases of COVID-19 are characterized by hyperinflammation induced by cytokine
storm, ARDS leading to multiorgan failure and death. JAK-STAT signaling has been …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was the seventh
known human coronavirus, and it was identified in Wuhan, Hubei province, China, in 2020. It …

Background In inflamed tissue, immune cells are accumulated, and various intercellular
signals are involved in the pathogenesis. Janus kinases (JAKs) are typical tyrosine kinases …

Abstract Microwave-assisted reaction of 3, 5-bis ((E)-ylidene)-1-phosphonate-4-piperidones
3a‒g with azomethine ylide (produced through interaction of isatins 4 and sarcosine 5) …

Severe COVID-19 is a systemic disorder involving excessive inflammatory response,
metabolic dysfunction, multi-organ damage, and several clinical features. Here, we …

Abstract On 4 September, 2020, the US National Institutes of Health launched a new clinical
trial,“A Multicenter, Adaptive, Randomized Controlled Platform Trial of the Safety and …

There appear to be huge variations and aberrations in the reported data in COVID-19 2
years now into the pandemic. Conflicting data exist at almost every level and also in the …

Zika virus (ZIKV) is an emerging flavivirus that is causing significant public health concerns
worldwide because of its association with severe neurological disorders in both newborns …

Despite the advances in contemporary medicine and availability of numerous innovative
therapies, effective treatment and prevention of SARS-CoV-2 infections pose a challenge. In …

Background and Objectives There is still incomplete understanding of the pathogenesis of
COVID-19. Calcitriol, the main form of vitamin D in serum, regulates immune responses and …