Therapeutic strategies for COVID-19: progress and lessons learned

G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

Broadly neutralizing antibodies to SARS-CoV-2 and other human coronaviruses

Y Chen, X Zhao, H Zhou, H Zhu, S Jiang… - Nature Reviews …, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently emerged
pathogenic human coronavirus that belongs to the sarbecovirus lineage of the genus …

Association of SARS-CoV-2 BA. 4/BA. 5 Omicron lineages with immune escape and clinical outcome

JA Lewnard, V Hong, JS Kim, SF Shaw, B Lewin… - Nature …, 2023 - nature.com
Expansion of the SARS-CoV-2 BA. 4 and BA. 5 Omicron subvariants in populations with
prevalent immunity from prior infection and vaccination, and associated burden of severe …

[HTML][HTML] Broadly neutralizing antibodies against COVID-19

D Zhou, J Ren, EE Fry, DI Stuart - Current Opinion in Virology, 2023 - Elsevier
The COVID-19 pandemic caused by SARS-CoV-2 has led to hundreds of millions of
infections and millions of deaths, however, human monoclonal antibodies (mAbs) can be an …

Potent antibodies against immune invasive SARS-CoV-2 Omicron subvariants

L Wang, Y Wang, H Zhou - International Journal of Biological …, 2023 - Elsevier
The development of neutralizing antibodies (nAbs) is an important strategy to tackle the
Omicron variant. Omicron N-terminal domain (NTD) mutations including A67V, G142D, and …

An overview of human anti-HIV-1 neutralizing antibodies against diverse epitopes of HIV-1

S Kumar, S Singh, K Luthra - ACS omega, 2023 - ACS Publications
In this Review, we have addressed some recent developments in the discovery and
applications of anti-human immunodeficiency virus type− 1 (HIV− 1) broadly neutralizing …

Distinct conformations of SARS-CoV-2 Omicron spike protein and its interaction with ACE2 and antibody

M Lee, M Major, H Hong - International Journal of Molecular Sciences, 2023 - mdpi.com
Since November 2021, Omicron has been the dominant severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) variant that causes the coronavirus disease 2019 (COVID-19) …

SARS-CoV-2 neutralizing antibody bebtelovimab–a systematic scoping review and meta-analysis

MNY Liew, KP Kua, SWH Lee, KK Wong - Frontiers in Immunology, 2023 - frontiersin.org
Introduction The COVID-19 pandemic is a major global public health crisis. More than 2
years into the pandemic, effective therapeutic options remain limited due to rapid viral …

Broadly neutralizing antibodies to SARS-CoV-2 provide novel insights into the neutralization of variants and other human coronaviruses

P Bajpai, V Singh, A Chandele… - Frontiers in Cellular and …, 2022 - frontiersin.org
Seven coronaviruses are known to cause infection/disease in humans. Of these, human
coronavirus (HCoV)-229E and HCoV-NL63 are alphacoronaviruses (α-CoVs), whereas …

Structural basis for broad neutralization of human antibody against Omicron sublineages and evasion by XBB variant

H Sun, Y Wang, X Chen, Y Jiang, S Wang… - Journal of …, 2023 - Am Soc Microbiol
The continuous emergence of SARS-CoV-2 variants, particularly the newly circulating
Omicron XBB subvariants, has led to a significant reduction in the neutralizing potency and …