Risk factors of severe COVID-19: a review of host, viral and environmental factors

L Zsichla, V Müller - Viruses, 2023 - mdpi.com
The clinical course and outcome of COVID-19 are highly variable, ranging from
asymptomatic infections to severe disease and death. Understanding the risk factors of …

Innate and adaptive immunity during SARS-CoV-2 infection: biomolecular cellular markers and mechanisms

B Brown, V Ojha, I Fricke, SA Al-Sheboul, C Imarogbe… - Vaccines, 2023 - mdpi.com
The coronavirus 2019 (COVID-19) pandemic was caused by a positive sense single-
stranded RNA (ssRNA) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Cross-reactive serum and memory B-cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection

G Song, W He, S Callaghan, F Anzanello… - Nature …, 2021 - nature.com
Pre-existing immunity to seasonal endemic coronaviruses could have profound
consequences for antibody responses to SARS-CoV-2, induced from natural infection or …

Evaluation of high-throughput SARS-CoV-2 serological assays in a longitudinal cohort of patients with mild COVID-19: clinical sensitivity, specificity, and association …

A Bal, B Pozzetto, MA Trabaud, V Escuret… - Clinical …, 2021 - academic.oup.com
Background The association between SARS-CoV-2 commercial serological assays and
virus neutralization test (VNT) has been poorly explored in mild patients with COVID-19 …

COVID-19 hospitalization rates rise exponentially with age, inversely proportional to thymic T-cell production

S Palmer, N Cunniffe… - Journal of the Royal …, 2021 - royalsocietypublishing.org
Here, we report that COVID-19 hospitalization rates follow an exponential relationship with
age, doubling for every 16 years of age or equivalently increasing by 4.5% per year of life (R …

An immunological review of SARS-CoV-2 infection and vaccine serology: innate and adaptive responses to mRNA, adenovirus, inactivated and protein subunit …

SA Al-Sheboul, B Brown, Y Shboul, I Fricke… - Vaccines, 2022 - mdpi.com
The coronavirus disease 2019 (COVID-19) pandemic is caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, which is defined by its positive …

Can we protect pregnant women and young infants from COVID-19 through maternal immunization?

FM Munoz - JAMA pediatrics, 2021 - jamanetwork.com
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during
pregnancy and early infancy can result in severe disease. 1-3 Less is known about the …

The spike of SARS-CoV-2: uniqueness and applications

R Kumavath, D Barh, BS Andrade, M Imchen… - Frontiers in …, 2021 - frontiersin.org
The Spike (S) protein of the SARS-CoV-2 virus is critical for its ability to attach and fuse into
the host cells, leading to infection, and transmission. In this review, we have initially …

Antibody responses to COVID‐19 vaccines in older adults

R Bag Soytas, M Cengiz, MS Islamoglu… - Journal of Medical …, 2022 - Wiley Online Library
Because of the senescence of the immune system, antibody response to the COVID‐19
vaccines may differ from older to younger adults. The study aim compares the titers of SARS …

Does the COVID‐19 seroconversion in older adults resemble the young?

R Bag Soytas, M Cengiz, MS Islamoglu… - Journal of medical …, 2021 - Wiley Online Library
High antibody titers have been found to correlate with the severity of coronavirus disease
2019 (COVID‐19) disease. Therefore, antibody titers may be higher in older adults, whose …