The genetic information of human cells is stored in the context of chromatin, which is
subjected to DNA methylation and various histone modifications. Such a 'language'of …

Epigenetic alternations concern heritable yet reversible changes in histone or DNA
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …

Both oncogenic mutations and cancer tissue-of-origin influence BCAA metabolism and
expression of BCAA-associated metabolic enzymes. These new discoveries need to be …

Epithelial-to-mesenchymal transition (EMT) is a process in which epithelial cells lose their
junctions and polarity to gain a motile mesenchymal phenotype. EMT is essential during …

The organization of eukaryotic genomes into chromatin provides challenges for the cell to
accomplish basic cellular functions, such as transcription, DNA replication and repair of DNA …

Epigenetic alterations, along with genetic alterations, have long been regarded as the most
important mechanism participating in carcinogenesis. DNA methylation, histone …

Epithelial-to-mesenchymal transition (EMT) is a process by which cells lose their epithelial
characteristics and gain mesenchymal phenotypes. In cancer, EMT is thought to drive tumor …

The histone methyltransferase DOT1L methylates lysine 79 (K79) on histone H3 and is
involved in Mixed Lineage Leukemia (MLL) fusion leukemogenesis; however, its role in …

Breast cancer is a heterogeneous disease, and triple-negative breast cancer (TNBC)
continues to be a serious health problem. The potential involvement of lncRNAs in TNBC …

Cancer was thought to be caused solely by genetic mutations in oncogenes and tumor
suppressor genes. In the last 35 years, however, epigenetic changes have been …