Background There has been increased interest in using multiple observational databases to
understand the safety profile of medical products during the postmarketing period. However …

Objectives We aimed to summarize the known risk of vasculopathy (stroke, myocardial
infarction [MI], and transient ischemic attack [TIA]) after herpes zoster (HZ) and the impact of …

BACKGROUND The risk of ischemic stroke/thromboembolic events after an intracranial
hemorrhage (ICH) in patients with atrial fibrillation (AF) who are on warfarin treatment is …

Background Postlicensure studies have shown an association between rotavirus
vaccination and intussusception. We assessed the risk of intussusception associated with …

Post-marketing vaccine safety surveillance aims to detect adverse events following
immunization in a population. Whether certain methods of surveillance are more precise and …

Background Leukotriene receptor antagonists (LTRAs) are widely used for asthma and
allergic rhinitis (AR), but concerns about the risk of neuropsychiatric events (NPEs) have …

Background Observational studies are widely used in pharmacoepidemiology. Several
designs can be used, in particular self-controlled designs (case-crossover and self …

Objective To assess the magnitude and duration of any hypothesised protective effect of
household exposure to a child with varicella on the relative incidence of herpes zoster in …

Comprehensive surveillance of adverse events following immunization (AEFI) is required to
detect potential serious adverse events that may not be identified in prelicensure vaccine …

The self-controlled case series method may be used to study the association between a time-
varying exposure and a health event. It is based only on cases, and it controls for fixed …