Resistance to chemotherapy and molecularly targeted therapies is a major problem facing
current cancer research. The mechanisms of resistance to'classical'cytotoxic …

The process of apoptosis is essential for maintaining the physiologic balance between cell
death and cell growth. This complex process is executed by two major pathways that …

Irrespective of the morphological features of end-stage cell death (that may be apoptotic,
necrotic, autophagic, or mitotic), mitochondrial membrane permeabilization (MMP) is …

Gallic acid, a predominant polyphenol, has been shown to inhibit carcinogenesis in animal
models and in vitro cancerous cell lines. The inhibitory effect of gallic acid on cancer cell …

Numerous innate and adaptive immune effector cells and molecules participate in the
recognition and destruction of cancer cells, a process that is known as cancer …

Traditional Chinese medicines have been recently recognized as a new source of
anticancer drugs and new chemotherapy adjuvant to enhance the efficacy of chemotherapy …

FAS belongs to the subgroup of the tumor necrosis factor receptor (TNF-R) family that
contains an intracellular" death domain" and triggers apoptosis. Its physiological ligand …

Clathrin-mediated endocytosis, the major pathway for ligand internalization into eukaryotic
cells, is thought to be initiated by the clustering of clathrin and adaptors around receptors …

Lysosomes are the key degradative compartments of the cell. Lysosomal cathepsins, which
are enclosed in the lysosomes, help to maintain the homeostasis of the cell's metabolism by …

Several of the inhibitor of apoptosis protein (IAP) family members regulate apoptosis in
response to various cellular assaults. Some members are also involved in cell signalling …