Male middle age is a transitional period where many physiological and psychological
changes occur leading to cognitive and behavioural alterations, and a deterioration of brain …

Prevalence of asthma in older adults is growing along with increasing global life expectancy.
Due to poor clinical consequences such as high mortality, advancement in understanding …

Introduction Aging causes several changes in the immune system, although immune aging
is strongly influenced by individual immunological history, as well as genetic and …

Immunosenescence is a term used to describe the age-related changes in the immune
system. Immunosenescence is associated with complex alterations and dysregulation of …

The immunophenotype of oldest centenarians, ie semi-and supercentenarians, could
provide important information about their ability to adapt to factors associated with immune …

Cell‐free DNA (cfDNA) is present in the circulating plasma and other body fluids and is
known to originate mainly from apoptotic cells. Here, we provide the first in vivo evidence of …

The primary goal of vaccination is the prevention of pathogen-specific infection. The indirect
consequences may include maintenance of homeostasis through prevention of infection …

Background Neutrophils and lymphocytes represent the larger percentage of all white blood
cells, they vary with age, with a progressive increase of the ratio in the first years of life, and …

Abstract As of June 2020, Coronavirus Disease 2019 (COVID-19) has killed an estimated
440 000 people worldwide, 74% of whom were aged≥ 65 years, making age the most …

A chronic low-grade inflammation is one of the hallmarks of the aging process. This
gradually augmenting inflammatory state has been termed inflammaging. Inflammaging is …