[HTML][HTML] What if there's no such thing as “aging”?

AA Cohen, V Legault, T Fülöp - Mechanisms of ageing and development, 2020 - Elsevier
Are diseases caused by aging? What are the mechanisms of aging? Do all species age?
These hotly debated questions revolve around a unitary definition of aging. Because we use …

Inflammaging at the Time of COVID-19

MB Zazzara, A Bellieni, R Calvani… - Clinics in Geriatric …, 2022 - geriatric.theclinics.com
Inflammaging and SARS-CoV-2 infection interact in an interplay that involves both acute
inflammation and low-grade chronic inflammation, predisposing older adults to severe …

Shelter from the cytokine storm: pitfalls and prospects in the development of SARS-CoV-2 vaccines for an elderly population

A Ciabattini, P Garagnani, F Santoro… - Seminars in …, 2020 - Springer
The SARS-CoV-2 pandemic urgently calls for the development of effective preventive tools.
COVID-19 hits greatly the elder and more fragile fraction of the population boosting the …

Sex and gender affect immune aging

A Calabrò, G Accardi, A Aiello, C Caruso… - Frontiers in …, 2023 - frontiersin.org
The proposed review aims to elucidate the intricate interplay between biological factors (sex
differences) and socially constructed factors (gender differences) in the context of immune …

Macrophage immunometabolism and inflammaging: roles of mitochondrial dysfunction, cellular senescence, CD38, and NAD

JR Yarbro, RS Emmons, BD Pence - Immunometabolism, 2020 - journals.lww.com
Aging is a complex process that involves dysfunction on multiple levels, all of which seem to
converge on inflammation. Macrophages are intimately involved in initiating and resolving …

The aging thyroid: a reappraisal within the geroscience integrated perspective

C Franceschi, R Ostan, S Mariotti, D Monti… - Endocrine …, 2019 - academic.oup.com
The thyroid plays a crucial and pervasive role in physiology (metabolism, thermogenesis,
and immunity, among others) and its aging and related changes in thyroid hormone …

The challenge by multiple environmental and biological factors induce inflammation in aging: their role in the promotion of chronic disease

MC Bachmann, S Bellalta, R Basoalto… - Frontiers in …, 2020 - frontiersin.org
The aging process is driven by multiple mechanisms that lead to changes in energy
production, oxidative stress, homeostatic dysregulation and eventually to loss of functionality …

Natural polyphenols as immunomodulators to rescue immune response homeostasis: Quercetin as a research model against severe COVID-19

R Bernini, F Velotti - Molecules, 2021 - mdpi.com
The COVID-19 pandemic is caused by SARS-CoV-2 and is leading to the worst health crisis
of this century. It emerged in China during late 2019 and rapidly spread all over the world …

Effects of resistance training on C-Reactive Protein and inflammatory cytokines in elderly adults: a systematic review and meta-analysis of randomized controlled trials

SD Kim, YR Yeun - International Journal of Environmental Research and …, 2022 - mdpi.com
Chronic low-grade inflammation that accompanies aging is associated with adverse health
outcomes and may exacerbate the severity of infectious disease such as COVID-19 …

Cellular immunity is critical for assessing COVID-19 vaccine effectiveness in immunocompromised individuals

E Paramithiotis, S Sugden, E Papp… - Frontiers in …, 2022 - frontiersin.org
COVID-19 vaccine clinical development was conducted with unprecedented speed.
Immunity measurements were concentrated on the antibody response which left significant …