Epigenetic regulatory mechanisms, including DNA methylation, histone modification,
chromatin remodeling, and microRNA expression, play critical roles in cell differentiation …

Respiratory cilia are the driving force of the mucociliary escalator, working in conjunction
with secreted airway mucus to clear inhaled debris and pathogens from the conducting …

The nucleus is considered the ideal target for anti‐tumor therapy because DNA and some
enzymes in the nucleus are the main causes of cell canceration and malignant proliferation …

Microbial dysbiosis in the skin has been implicated in the pathogenesis of atopic dermatitis
(AD); however, whether and how changes in the skin microbiome initiate skin inflammation …

Hepatocellular carcinoma (HCC) is a deadly tumour whose causative agents are generally
well known, but whose pathogenesis remains poorly understood. Nevertheless, key genetic …

Atopic dermatitis (AD) is a globally prevalent skin inflammation with a particular impact on
children. Current therapies for AD are challenged by the limited armamentarium and the …

The initiation of osteogenesis primarily occurs as mesenchymal stem cells undergo
differentiation into osteoblasts. This differentiation process plays a crucial role in bone …

Neuropathic pain is a challenging clinical problem and remains difficult to treat. Altered gene
expression in peripheral sensory nerves and neurons due to nerve injury is well …

As widely acknowledged, 40–50% of all melanoma patients harbour an activating BRAF
mutation (mostly BRAF V600E). The identification of the RAS–RAF–MEK–ERK (MAP kinase) …

Histone deacetylase (HDAC) inhibitors used in the clinic typically contain a hydroxamate
zinc-binding group (ZBG). However, more recent work has shown that the use of alternative …