Cells' local mechanical environment can be as important in guiding cellular responses as
many well-characterized biochemical cues. Hydrogels that mimic the native extracellular …

The term 'fibroblast'often serves as a catch-all for a diverse array of mesenchymal cells,
including perivascular cells, stromal progenitor cells and bona fide fibroblasts. Although …

The term 'mechanosensation'describes the capacity of cells to translate mechanical stimuli
into the coordinated regulation of intracellular signals, cellular function, gene expression …

Mechanobiology studies the mechanisms by which cells sense and respond to physical
forces, and the role of these forces in shaping cells and tissues themselves …

From embryonic development, postnatal growth and adult homeostasis to reparative and
disease states, cells and tissues undergo constant changes in genome activity, cell fate …

The ability to maintain and differentiate cells in vitro is critical to many advances in the field
of bioengineering. However, on traditional, stiff (E≈ GPa) culture substrates, cells are …

The interplay between mechanical stimuli and cellular mechanobiology orchestrates the
physiology of tissues and organs in a dynamic balance characterized by constant …

All life forms sense and respond to mechanical stimuli. Throughout evolution, organisms
develop diverse mechanosensing and mechanotransduction pathways, leading to fast and …

Morphogenesis and cell state transitions must be coordinated in time and space to produce
a functional tissue. An excellent paradigm to understand the coupling of these processes is …

Mechanically sensitive tissues (eg, skeletal muscles) greatly need mechanical stimuli during
the development and maturation. The extracellular matrix (ECM) mediates these signals …