The brain relies on many forms of dynamic activities in individual neurons, from synaptic
transmission to electrical activity and intracellular signaling events. Monitoring these …

Genetically encoded fluorescent indicators are powerful tools for tracking cellular dynamic
processes. Engineering these indicators requires balancing screening dimensions with …

Biosensors based on Förster resonance energy transfer (FRET) have revolutionized
cellular biology by allowing the direct measurement of biochemical processes in situ. Many …

Genetically encoded fluorescent calcium indicators have revolutionized neuroscience and
other biological fields by allowing cellular-resolution recording of physiology during …

Near-infrared fluorescent protein (iRFP) is a bright and stable fluorescent protein with near-
infrared excitation and emission maxima. Unlike the other conventional fluorescent proteins …

Genetically encoded fluorescent indicators of neuronal activity are ultimately developed to
dissect functions of neuronal ensembles during behavior in living animals. Recent …

Molecular signals interact in networks to mediate biological processes. To analyze these
networks, it would be useful to image many signals at once, in the same living cell, using …

Ca 2+ plays many critical roles in cell physiology and biochemistry, leading researchers to
develop a number of fluorescent small molecule dyes and genetically encodable probes that …

Optogenetic (photo-responsive) actuators engineered from photoreceptors are widely used
in various applications to study cell biology and tissue physiology. In the toolkit of …

Here, we present simultaneous fiber photometry recordings and optogenetic stimulation
based on a multimode fused fiber coupler for both light delivery and collection without the …