Purpose Consensus is needed on conceptual foundations, terminology and relationships
among the various self‐controlled “trigger” study designs that control for time‐invariant …

Background Observational studies are widely used in pharmacoepidemiology. Several
designs can be used, in particular self-controlled designs (case-crossover and self …

The tree-based scan statistic is a statistical data mining tool that has been used for signal
detection with a self-controlled design in vaccine safety studies. This disproportionality …

Purpose The case‐crossover design is a self‐controlled study design used to compare
exposure immediately preceding an event occurrence with exposure in earlier control …

Introduction A safety signal concerning parkinsonism and related movement disorders with
gabapentinoids (gabapentin and pregabalin) or tramadol was detected by reviewing …

We sought to develop a semiautomated screening approach using electronic healthcare
data to identify drug–drug interactions (DDIs) that result in clinical outcomes. Using a case …

Purpose The case‐crossover design is increasingly used to evaluate the effects of chronic
medications; however, as traditionally implemented in pharmacoepidemiology, with referent …

Objective: to evaluate and analyze health product-related technical complaints and adverse
events at Maranhão Federal University Hospital. Methods: from January to December 2015 …

Background: Safety issues are detected in about one third of prescription drugs in the years
following regulatory agency approval. Older adults, especially those with chronic kidney …

Objectives Inappropriate use of the case-crossover design, which is efficient for examining
associations between brief exposure and abrupt outcomes, in evaluating the effects of …