The present narrative review examines the scientific evidence of the biological mechanisms
that may link periodontitis and diabetes, as a source of comorbidity. Publications regarding …

Most diseases are the consequence of the breakdown of cellular processes, but the
relationships among genetic/epigenetic defects, the molecular interaction networks …

Background Several recent studies reported aging effects on DNA methylation levels of
individual CpG dinucleotides. But it is not yet known whether aging-related consensus …

In many applications, one is interested in determining which of the properties of a network
module change across conditions. For example, to validate the existence of a module, it is …

Rapidly increasing amounts of molecular interaction data are being produced by various
experimental techniques and computational prediction methods. In order to gain insight into …

Computational analysis and interactive visualization of biological networks and protein
structures are common tasks for gaining insight into biological processes. This protocol …

Since hub nodes have been found to play important roles in many networks, highly
connected hub genes are expected to play an important role in biology as well. However …

Networks are typically visualized with force-based or spectral layouts. These algorithms lack
reproducibility and perceptual uniformity because they do not use a node coordinate system …

Although the genetic causes for several rare, familial forms of Alzheimer's disease (AD) have
been identified, the etiology of the sporadic form of AD remains unclear. Here, we report a …

Infectious diseases result in millions of deaths each year. Mechanisms of infection have
been studied in detail for many pathogens. However, many questions are relatively …