[PDF][PDF] 生物网络比对的模型与算法

郭杏莉, 高琳, 陈新 - 软件学报, 2010 - jos.org.cn
生物网络比对是生物体结构, 功能和进化分析的重要研究手段. 首先给出了生物网络比对问题的
形式化定义; 其次重点分析了现有的比对模型和算法, 按照比对方法的数学特性对其进行了分类 …

Network approach of the conformational change of c-Src, a tyrosine kinase, by molecular dynamics simulation

HJ Yoon, S Lee, SJ Park, S Wu - Scientific reports, 2018 - nature.com
Non-receptor tyrosine kinase c-Src plays a critical role in numerous cellular signalling
pathways. Activation of c-Src from its inactive to the active state involves large-scale …

Investigation of Precise Molecular Mechanistic Action of Tobacco-Associated Carcinogen 'NNK'Induced Carcinogenesis: A System Biology Approach

Anukriti, A Dhasmana, S Uniyal, P Somvanshi… - Genes, 2019 - mdpi.com
Cancer is the second deadliest disease listed by the WHO. One of the major causes of
cancer disease is tobacco and consumption possibly due to its main component, 4 …

Anti-inflammatory mechanism research of tanshinone II A by module-based network analysis

S Zheng, Z Ren, Y Zhang… - Bio-medical Materials and …, 2014 - content.iospress.com
Abstract Tanshinone IIA (Tan IIA) is one of the major fat-soluble ingredients in Salvia
miltiorrhiza which has been widely used for various inflammatory conditions associated with …

Socioeconomic status and bone health in community-dwelling older men: the CHAMP Study

I Nabipour, R Cumming, DJ Handelsman… - Osteoporosis …, 2011 - Springer
The association between socioeconomic status (SES) and bone health, specifically in men,
is unclear. Based upon data from the large prospective Concord Health in Ageing Men …

The number of catalytic elements is crucial for the emergence of metabolic cores

IM De la Fuente, F Vadillo, MB Perez-Pinilla… - Plos One, 2009 - journals.plos.org
Background Different studies show evidence that several unicellular organisms display a
cellular metabolic structure characterized by a set of enzymes which are always in an active …

Global self-regulation of the cellular metabolic structure

IM De la Fuente, F Vadillo, AL Pérez-Samartín… - PLoS …, 2010 - journals.plos.org
Background Different studies have shown that cellular enzymatic activities are able to self-
organize spontaneously, forming a metabolic core of reactive processes that remain active …

NAIGO: an improved method to align PPI networks based on gene ontology and graphlets

L Zhu, J Zhang, Y Zhang, J Lang, J Xiang… - … in bioengineering and …, 2020 - frontiersin.org
With the development of high throughput technologies, there are more and more protein–
protein interaction (PPI) networks available, which provide a need for efficient computational …

The metabolic core and catalytic switches are fundamental elements in the self-regulation of the systemic metabolic structure of cells

IM De la Fuente, JM Cortes, MB Perez-Pinilla… - Plos One, 2011 - journals.plos.org
Background Experimental observations and numerical studies with dissipative metabolic
networks have shown that cellular enzymatic activity self-organizes spontaneously leading …

Information flow during gene activation by signaling molecules: ethylene transduction in Arabidopsis cells as a study system

J Díaz, ER Alvarez-Buylla - BMC Systems Biology, 2009 - Springer
Background We study root cells from the model plant Arabidopsis thaliana and the
communication channel conformed by the ethylene signal transduction pathway. A basic …