Natural compounds and products from an anti-aging perspective
Aging is a very complex process that is accompanied by a degenerative impairment in many
of the major functions of the human body over time. This inevitable process is influenced by …
of the major functions of the human body over time. This inevitable process is influenced by …
Risk factors of severe COVID-19: a review of host, viral and environmental factors
The clinical course and outcome of COVID-19 are highly variable, ranging from
asymptomatic infections to severe disease and death. Understanding the risk factors of …
asymptomatic infections to severe disease and death. Understanding the risk factors of …
SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence
U Gioia, S Tavella, P Martínez-Orellana, G Cicio… - Nature Cell …, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the RNA virus
responsible for the coronavirus disease 2019 (COVID-19) pandemic. Although SARS-CoV-2 …
responsible for the coronavirus disease 2019 (COVID-19) pandemic. Although SARS-CoV-2 …
Biological age is increased by stress and restored upon recovery
Aging is classically conceptualized as an ever-increasing trajectory of damage accumulation
and loss of function, leading to increases in morbidity and mortality. However, recent in vitro …
and loss of function, leading to increases in morbidity and mortality. However, recent in vitro …
[HTML][HTML] DNA methylation GrimAge version 2
We previously described a DNA methylation (DNAm) based biomarker of human mortality
risk DNAm GrimAge. Here we describe version 2 of GrimAge (trained on individuals aged …
risk DNAm GrimAge. Here we describe version 2 of GrimAge (trained on individuals aged …
Human age reversal: Fact or fiction?
AA Johnson, BW English, MN Shokhirev… - Aging …, 2022 - Wiley Online Library
Although chronological age correlates with various age‐related diseases and conditions, it
does not adequately reflect an individual's functional capacity, well‐being, or mortality risk …
does not adequately reflect an individual's functional capacity, well‐being, or mortality risk …
Long-COVID cognitive impairments and reproductive hormone deficits in men may stem from GnRH neuronal death
Background We have recently demonstrated a causal link between loss of gonadotropin-
releasing hormone (GnRH), the master molecule regulating reproduction, and cognitive …
releasing hormone (GnRH), the master molecule regulating reproduction, and cognitive …
Causal association of epigenetic aging and COVID-19 severity and susceptibility: A bidirectional Mendelian randomization study
W Xu, F Zhang, Y Shi, Y Chen, B Shi, G Yu - Frontiers in Medicine, 2022 - frontiersin.org
Observational data from China, the United States, France, and Italy suggest that
chronological age is an adverse COVID-19 outcome risk factor, with older patients having a …
chronological age is an adverse COVID-19 outcome risk factor, with older patients having a …
Long COVID or post-COVID-19 condition: past, present and future research directions
C Fernández-de-Las-Peñas, AV Raveendran… - Microorganisms, 2023 - mdpi.com
The presence of symptoms after an acute SARS-CoV-2 infection (long-COVID) has become
a worldwide healthcare emergency but remains underestimated and undertreated due to a …
a worldwide healthcare emergency but remains underestimated and undertreated due to a …
From aging to long COVID: exploring the convergence of immunosenescence, inflammaging, and autoimmunity
L Müller, S Di Benedetto - Frontiers in Immunology, 2023 - frontiersin.org
The process of aging is accompanied by a dynamic restructuring of the immune response, a
phenomenon known as immunosenescence. This mini-review navigates through the …
phenomenon known as immunosenescence. This mini-review navigates through the …