Hair follicle-MSC-derived small extracellular vesicles as a novel remedy for acute pancreatitis

S Li, H Li, H Zhangdi, R Xu, X Zhang, J Liu, Y Hu… - Journal of Controlled …, 2022 - Elsevier
Background Hair follicle-derived mesenchymal stem cell (HF-MSC)-based therapies protect
against acute pancreatitis (AP). However, accumulating evidence suggests that MSC-based …

New insights into regulatory cell death and acute pancreatitis

H Li, D Wu, H Zhang, P Li - Heliyon, 2023 - cell.com
Acute pancreatitis (AP) may be associated with both local and systemic complications.
Although it is usually self-limiting, up to 20% of patients develop severe acute pancreatitis …

Sulfiredoxin-1 attenuates injury and inflammation in acute pancreatitis through the ROS/ER stress/Cathepsin B axis

J He, M Ma, D Li, K Wang, Q Wang, Q Li, H He… - Cell death & …, 2021 - nature.com
Acinar cell injury and the inflammatory response are critical bioprocesses of acute
pancreatitis (AP). We investigated the role and underlying mechanism of sulfiredoxin-1 …

Myeloid‐specific dopamine D2 receptor signalling controls inflammation in acute pancreatitis via inhibiting M1 macrophage

X Han, J Ni, Z Wu, J Wu, B Li, X Ye, J Dai… - British journal of …, 2020 - Wiley Online Library
Background and Purpose Macrophage infiltration and activation is a critical step during
acute pancreatitis (AP). We have shown that pancreas‐specific D2 receptor signalling …

Understanding the effects of metabolites on the gut microbiome and severe acute pancreatitis

S Ye, C Si, J Deng, X Chen, L Kong… - BioMed Research …, 2021 - Wiley Online Library
Acute pancreatitis (AP) is an inflammatory disease of the pancreas. The severity is classified
as mild (MAP), moderately severe (MSAP), or severe (SAP). In patients with SAP, organ …

Integration of scRNA-Seq and bulk RNA-Seq reveals molecular characterization of the immune microenvironment in acute pancreatitis

Z Fang, J Li, F Cao, F Li - Biomolecules, 2022 - mdpi.com
Acute pancreatitis (AP) is an acute inflammatory disease of the exocrine pancreas. The
pathogenesis of AP is still unclear, and there is currently no specific treatment. A variety of …

Ruthenium red attenuates acute pancreatitis by inhibiting MCU and improving mitochondrial function

X Yu, C Dai, X Zhao, Q Huang, X He, R Zhang… - Biochemical and …, 2022 - Elsevier
Acute pancreatitis (AP) is a common inflammatory disease of the digestive system.
Mitochondrial calcium uniporter (MCU) mediates mitochondrial uptake of Ca 2+ and plays …

Glucose levels show independent and dose-dependent association with worsening acute pancreatitis outcomes: Post-hoc analysis of a prospective, international …

A Nagy, MF Juhász, A Görbe, A Váradi, F Izbéki… - Pancreatology, 2021 - Elsevier
Background Metabolic risk factors, such as obesity, hypertension, and hyperlipidemia are
independent risk factors for the development of various complications in acute pancreatitis …

Ameliorative effects of gut microbial metabolite urolithin a on pancreatic diseases

K Li, Y Xiao, J Bian, L Han, C He, E El-Omar, L Gong… - Nutrients, 2022 - mdpi.com
Urolithin A (Uro A) is a dietary metabolite of the intestinal microbiota following the ingestion
of plant-based food ingredients ellagitannins and ellagic acid in mammals. Accumulating …

GDF11 ameliorates severe acute pancreatitis through modulating macrophage M1 and M2 polarization by targeting the TGFβR1/SMAD-2 pathway

F Duan, X Wang, H Wang, Y Wang, Y Zhang… - International …, 2022 - Elsevier
Severe acute pancreatitis (SAP), as a typical acute inflammatory injury disease, is one of the
acute gastrointestinal diseases with a remarkable mortality rate. Macrophages, typical …