GDF11 ameliorates severe acute pancreatitis through modulating macrophage M1 and M2 polarization by targeting the TGFβR1/SMAD-2 pathway

F Duan, X Wang, H Wang, Y Wang, Y Zhang… - International …, 2022 - Elsevier
Severe acute pancreatitis (SAP), as a typical acute inflammatory injury disease, is one of the
acute gastrointestinal diseases with a remarkable mortality rate. Macrophages, typical …

Biochanin A ameliorates caerulein-induced acute pancreatitis and associated intestinal injury in mice by inhibiting TLR4 signaling

X Pan, L Ye, Z Ren, J Li, B Li, LL Pan, J Sun - The Journal of Nutritional …, 2023 - Elsevier
Acute pancreatitis (AP) is an acute inflammatory abdominal disease frequently associated
with intestinal barrier dysfunction. Biochanin A (BCA), a dietary isoflavone, has gained …

Milk fat globule EGF factor 8 restores mitochondrial function via integrin‐medicated activation of the FAK‐STAT3 signaling pathway in acute pancreatitis

Y Ren, W Liu, L Zhang, J Zhang, J Bi… - Clinical and …, 2021 - Wiley Online Library
Acute pancreatitis (AP) remains a significant clinical challenge. Mitochondrial dysfunction
contributes significantly to the pathogenesis of AP. Milk fat globule EGF factor 8 (MFG‐E8) is …

[HTML][HTML] Role of lncRNAs in acute pancreatitis: pathogenesis, diagnosis, and therapy

J Deng, Z Song, X Li, H Shi, S Huang, L Tang - Frontiers in Genetics, 2023 - frontiersin.org
Acute pancreatitis (AP) is one of the most common acute abdominal diseases characterized
by an injury and inflammatory disorder of the pancreas with complicated pathological …

Advances in the management of acute pancreatitis

E de-Madaria, JL Buxbaum - Nature Reviews Gastroenterology & …, 2023 - nature.com
Recent randomized controlled trials in acute pancreatitis have provided evidence that
challenges current approaches to management, including fluid resuscitation, antibiotic …

[HTML][HTML] Genetic determinants of pancreatitis: relevance in severe hypertriglyceridemia

SMT Hang, RA Hegele… - Current Opinion in …, 2023 - journals.lww.com
Currently, among patients with severe hypertriglyceridemia, the most consistent predictor of
pancreatitis risk is the triglyceride level. Furthermore, pancreatitis risk appears to be …

[HTML][HTML] The Interaction of Microbiome and Pancreas in Acute Pancreatitis

C Zhang, G Li, T Lu, L Liu, Y Sui, R Bai, L Li, B Sun - Biomolecules, 2023 - mdpi.com
Acute pancreatitis (AP) is a common acute abdomen disease characterized by the
pathological activation of digestive enzymes and the self-digestion of pancreatic acinar cells …

Rapid reduction in triglyceride levels by therapeutic plasma exchange in patients with hypertriglyceridemic pancreatitis

Z Chen, X Huang, M Zhang, N Han… - Journal of Clinical …, 2022 - Wiley Online Library
Objective To investigate the effect of therapeutic plasma exchange (TPE) on lowering
triglyceride (TG) levels in patients with hypertriglyceridemic pancreatitis (HLAP). Methods …

[HTML][HTML] Targeting macrophage migration inhibitory factor in acute pancreatitis and pancreatic cancer

Y Wen, W Cai, J Yang, X Fu, L Putha, Q Xia… - Frontiers in …, 2021 - frontiersin.org
Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine implicated in the
pathogenesis of inflammation and cancer. It is produced by various cells and circulating MIF …

Pancreatitis and pancreatic cancer risk

DM Ma, XW Dong, X Han, Z Ling… - … in Cancer Research …, 2023 - journals.sagepub.com
Purpose: The present retrospective study aimed to explore the relationship between
pancreatitis and pancreatic cancer in the population cohort of the UK Biobank …