Psychological stress is a major factor contributing to health discrepancies among
individuals. Sustained exposure to stress triggers signalling pathways in the brain, which …

Circadian rhythms govern a remarkable variety of metabolic and physiological functions.
Accumulating epidemiological and genetic evidence indicates that the disruption of …

Here we describe a staged, behavioral testing approach that can be used to screen for
compounds that exhibit in vivo efficacy on cognitive and functional motor behaviors in …

Collectively the daily, seasonal, lunar and tidal geophysical cycles regulate much of the
temporal biology of life on Earth. The increasing isolation of human societies from these …

PERIOD (PER) proteins are central components within the mammalian circadian oscillator,
and are believed to form a negative feedback complex that inhibits their own transcription at …

Behavior is a complex phenotype that is plastic and evolutionarily labile. The advent of
genomics has revolutionized the field of behavioral genetics by providing tools to quantify …

The sequencing of the Strongylocentrotus purpuratus genome provides a unique
opportunity to investigate the function and evolution of neural genes. The neurobiology of …

Although obesity is considered to result from an imbalance between energy uptake and
energy expenditure, the strategy of dietary changes and physical exercise has failed to …

The circadian clock coordinates the daily cyclic rhythm of numerous biological processes by
regulating a large portion of the transcriptome. In animals, the circadian clock is involved in …

Resting-state functional MRI (rs-fMRI) permits study of the brain's functional networks without
requiring participants to perform tasks. Robust changes in such resting state networks …