Sacrificial templates for patterning perfusable vascular networks in engineered tissues have
been constrained in architectural complexity, owing to the limitations of extrusion-based 3D …

Titanium and its alloys are commonly used in almost all disciplines of medicine because of
their sufficient biocompatibility and meeting of mechanical requirements. However, dense …

Silica nanomaterials (SNMs) and their composites have recently been investigated as
scaffolds for bone tissue engineering. SNM scaffolds possess the ability to encourage bone …

In 1892, JL Wolff proposed that bone could respond to mechanical and biophysical stimuli
as a dynamic organ. This theory presents a unique opportunity for investigations on bone …

Bone vasculature plays a vital role in bone development, remodeling and homeostasis. New
blood vessel formation is crucial during both primary bone development as well as fracture …

Bioprinting of living cells is rapidly developing as an advanced biofabrication approach to
engineer tissues. Bioinks can be extruded in three-dimensions (3D) to fabricate complex …

Vascularization of large bone grafts is one of the main challenges of bone tissue
engineering (BTE), and has held back the clinical translation of engineered bone constructs …

In the last two decades, additive manufacturing (AM) has made significant progress towards
the fabrication of biomaterials and tissue engineering constructs. One direction of research …

Microvasculature functions at the tissue and cell level, regulating local mass exchange of
oxygen and nutrient-rich blood. While there has been considerable success in the …

Insufficient vascularization during tissue repair is often associated with poor clinical
outcomes. This is a concern especially when patients have critical‐sized injuries, where the …