Abstract Effect of octacalcium phosphate/gelatin composite (OCP/Gel) on angiogenesis was
studied by its implantation in rat calvaria critical-sized defect in relation to bone regeneration …

Bone regeneration is a complex process, that in vivo, requires the highly coordinated
presentation of biochemical cues to promote the various stages of angiogenesis and …

With the increasing importance of preclinical evaluation of newly developed drugs or
treatments, in vitro organ or disease models are necessary. Although various organ-specific …

The regeneration capacity of osteoporotic bones is generally lower than that of normal
bones. Current methods of osteoporotic bone defect treatment are not always satisfactory …

Engineering bone tissue requires the generation of a highly organized vasculature. Cellular
behavior is affected by the respective niche. Directing cellular behavior and differentiation …

Current strategies for regeneration of large bone fractures yield limited clinical success
mainly due to poor integration and healing. Multidisciplinary approaches in design and …

Bone, like most organs, has the ability to heal naturally and can be repaired slowly when it is
slightly injured. However, in the case of bone defects caused by diseases or large shocks …

Tissue Engineering (TE) is a scientific field mainly focused on the development of tissue and
organ substitutes by controlling biological, biophysical and/or biomechanical parameters in …

Vascularization of engineered bone tissue is critical for ensuring its survival after
implantation and it is the primary factor limiting its clinical use. A promising approach is to …

During the last decades, a range of excellent and promising strategies in Bone Tissue
Engineering have been developed. However, the remaining major problem is the lack of …