Towards a global view of multiple sclerosis genetics
Multiple sclerosis (MS) is a neuroimmunological disorder of the CNS with a strong heritable
component. The genetic architecture of MS susceptibility is well understood in populations of …
component. The genetic architecture of MS susceptibility is well understood in populations of …
Improving polygenic prediction in ancestrally diverse populations
Polygenic risk scores (PRS) have attenuated cross-population predictive performance. As
existing genome-wide association studies (GWAS) have been conducted predominantly in …
existing genome-wide association studies (GWAS) have been conducted predominantly in …
Genome-wide association studies of cardiovascular disease
R Walsh, SJ Jurgens, J Erdmann… - Physiological …, 2023 - journals.physiology.org
Genome-wide association studies (GWAS) aim to identify common genetic variants that are
associated with traits and diseases. Since 2005, more than 5,000 GWAS have been …
associated with traits and diseases. Since 2005, more than 5,000 GWAS have been …
[HTML][HTML] Transferability of genetic loci and polygenic scores for cardiometabolic traits in British Pakistani and Bangladeshi individuals
Abstract Individuals with South Asian ancestry have a higher risk of heart disease than other
groups but have been largely excluded from genetic research. Using data from 22,000 …
groups but have been largely excluded from genetic research. Using data from 22,000 …
Leveraging base-pair mammalian constraint to understand genetic variation and human disease
Thousands of genomic regions have been associated with heritable human diseases, but
attempts to elucidate biological mechanisms are impeded by an inability to discern which …
attempts to elucidate biological mechanisms are impeded by an inability to discern which …
[HTML][HTML] Development and validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations
T Ge, MR Irvin, A Patki, V Srinivasasainagendra… - Genome medicine, 2022 - Springer
Abstract Background Type 2 diabetes (T2D) is a worldwide scourge caused by both genetic
and environmental risk factors that disproportionately afflicts communities of color …
and environmental risk factors that disproportionately afflicts communities of color …
Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations
Polygenic scores (PGS) can identify individuals at risk of adverse health events and guide
genetics-based personalized medicine. However, it is not clear how well PGS translate …
genetics-based personalized medicine. However, it is not clear how well PGS translate …
[HTML][HTML] Quantifying portable genetic effects and improving cross-ancestry genetic prediction with GWAS summary statistics
Polygenic risk scores (PRS) calculated from genome-wide association studies (GWAS) of
Europeans are known to have substantially reduced predictive accuracy in non-European …
Europeans are known to have substantially reduced predictive accuracy in non-European …
[HTML][HTML] Polygenic Health Index, General Health, and Pleiotropy: Sibling Analysis and Disease Risk Reduction
We construct a polygenic health index as a weighted sum of polygenic risk scores for 20
major disease conditions, including, eg, coronary artery disease, type 1 and 2 diabetes …
major disease conditions, including, eg, coronary artery disease, type 1 and 2 diabetes …
[HTML][HTML] Multiethnic polygenic risk prediction in diverse populations through transfer learning
Polygenic risk scores (PRS) leverage the genetic contribution of an individual's genotype to
a complex trait by estimating disease risk. Traditional PRS prediction methods are …
a complex trait by estimating disease risk. Traditional PRS prediction methods are …