The unique morphological and excitable properties of nerve cells endow them with specialized properties that permit the reception, transmission, and storage of information. It …
The molecular mechanisms governing orderly shutdown and retraction of CD4+ type 1 helper T (TH1) cell responses remain poorly understood. Here we show that complement …
Chimeric antigen receptor (CAR) T cells mediate anti-tumour effects in a small subset of patients with cancer,–, but dysfunction due to T cell exhaustion is an important barrier to …
INTRODUCTION The ability to regenerate tissues lost to damage or disease is widely but nonuniformly distributed in vertebrates. Some animals such as teleost fishes can regenerate …
Although the proteins that read the gene regulatory code, transcription factors (TFs), have been largely identified, it is not well known which sequences TFs can recognize. We have …
JR Woodgett - The EMBO journal, 1990 - embopress.org
Glycogen synthase kinase‐3 (GSK‐3) is a protein‐serine kinase implicated in the hormonal control of several regulatory proteins including glycogen synthase and the transcription …
BB Aggarwal, S Shishodia - Biochemical pharmacology, 2006 - Elsevier
While fruits and vegetables are recommended for prevention of cancer and other diseases, their active ingredients (at the molecular level) and their mechanisms of action less well …
A plethora of physiological and pathological stimuli induce and activate a group of DNA binding proteins that form AP-1 dimers. These proteins include the Jun, Fos and ATF …
T Wada, JM Penninger - Oncogene, 2004 - nature.com
Cells are continuously exposed to a variety of environmental stresses and have to decide 'to be or not to be'depending on the types and strength of stress. Among the many signaling …