Magnetic resonance linear accelerator technology and adaptive radiation therapy: An overview for clinicians

WA Hall, E Paulson, XA Li, B Erickson… - CA: a cancer journal …, 2022 - Wiley Online Library
Radiation therapy (RT) continues to play an important role in the treatment of cancer.
Adaptive RT (ART) is a novel method through which RT treatments are evolving. With the …

Integrating mechanism-based modeling with biomedical imaging to build practical digital twins for clinical oncology

C Wu, G Lorenzo, DA Hormuth, EABF Lima… - Biophysics …, 2022 - pubs.aip.org
Digital twins employ mathematical and computational models to virtually represent a
physical object (eg, planes and human organs), predict the behavior of the object, and …

History of technological advancements towards MR-Linac: the future of image-guided radiotherapy

N Rammohan, JW Randall, P Yadav - Journal of Clinical Medicine, 2022 - mdpi.com
Image-guided radiotherapy (IGRT) enables optimal tumor targeting and sparing of organs-at-
risk, which ultimately results in improved outcomes for patients. Magnetic resonance …

ICRU REPORT 97: MRI-guided radiation therapy using MRI-linear accelerators

PJ Keall, CK Glide-Hurst, M Cao, P Lee… - Journal of the …, 2022 - journals.sagepub.com
The International Commission on Radiation Units and Measurements (ICRU), since its
inception in 1925, has had as its principal objective the development of internationally …

[HTML][HTML] First-in-human technique translation of oxygen-enhanced MRI to an MR Linac system in patients with head and neck cancer

MJ Dubec, DL Buckley, M Berks, A Clough… - Radiotherapy and …, 2023 - Elsevier
Background and purpose Tumour hypoxia is prognostic in head and neck cancer (HNC),
associated with poor loco-regional control, poor survival and treatment resistance. The …

Radiomics feature stability of open-source software evaluated on apparent diffusion coefficient maps in head and neck cancer

JC Korte, C Cardenas, N Hardcastle, T Kron, J Wang… - Scientific reports, 2021 - nature.com
Radiomics is a promising technique for discovering image based biomarkers of therapy
response in cancer. Reproducibility of radiomics features is a known issue that is addressed …

The future of MRI in radiation therapy: Challenges and opportunities for the MR community

RJ Goodburn, MEP Philippens… - Magnetic resonance …, 2022 - Wiley Online Library
Radiation therapy is a major component of cancer treatment pathways worldwide. The main
aim of this treatment is to achieve tumor control through the delivery of ionizing radiation …

Promising biomarkers of radiation-induced lung injury: a review

X Liu, C Shao, J Fu - Biomedicines, 2021 - mdpi.com
Radiation-induced lung injury (RILI) is one of the main dose-limiting side effects in patients
with thoracic cancer during radiotherapy. No reliable predictors or accurate risk models are …

[HTML][HTML] Integration of quantitative imaging biomarkers in clinical trials for MR-guided radiotherapy: Conceptual guidance for multicentre studies from the MR-Linac …

PJ van Houdt, H Saeed, D Thorwarth, CD Fuller… - European Journal of …, 2021 - Elsevier
Quantitative imaging biomarkers (QIBs) derived from MRI techniques have the potential to
be used for the personalised treatment of cancer patients. However, large-scale data are …

Daily Intravoxel Incoherent Motion (IVIM) in prostate cancer patients during MR-guided radiotherapy—a multicenter study

ES Kooreman, PJ van Houdt, R Keesman… - Frontiers in …, 2021 - frontiersin.org
Purpose Daily quantitative MR imaging during radiotherapy of cancer patients has become
feasible with MRI systems integrated with linear accelerators (MR-linacs). Quantitative …