Breast cancer is the most common malignancy in women worldwide. Metastasis is the
leading cause of high mortality in most cancers. Although predicting the early stage of breast …

Oncolytic viruses (OVs) represent a new class of multi-modal immunotherapies for cancer,
with OV-elicited antitumor immunity being key to their overall therapeutic efficacy. Currently …

Metabolic reprogramming and epigenetic modifications are hallmarks of cancer cells. In
cancer cells, metabolic pathway activity varies during tumorigenesis and cancer …

The advent of immunotherapy has made an indelible mark on the field of cancer therapy,
especially the application of immune checkpoint inhibitors in clinical practice. Although …

Nowadays, one of the leading causes of death in humans is cancer, which is still on the rise
globally and is in great need of intense study on the pathogenic mechanism and effective …

Ferroptosis is a non-apoptotic form of regulated cell death characterized by the lethal
accumulation of iron-dependent membrane-localized lipid peroxides. It acts as an innate …

Immunotherapy, particularly those based on immune checkpoint inhibitors (ICIs), has
become a useful approach for many neoplastic diseases. Despite the improvements of ICIs …

Pancreatic ductal adenocarcinoma (PDA) is a clinically challenging disease with limited
treatment options. Despite a small percentage of cases with defective mismatch DNA repair …

At the turn of the century, researchers discovered a unique subtype of T helper cells that
secretes IL-17 and defined it as Th17. The latest study found that Th17 cells play both …

Histone deacetylase (HDAC) is one of the most characterized epigenetic modifiers,
modulating chromatin structure and gene expression, which plays an important role in cell …