Modulatory polynucleotides
J Hou, ME Nonnenmacher, P Zhou - US Patent 10,570,395, 2020 - Google Patents
C12N15/113—Non-coding nucleic acids modulating the expression of genes, eg antisense
oligonucleotides; Antisense DNA or RNA; Triplex-forming oligonucleotides; Catalytic nucleic …
oligonucleotides; Antisense DNA or RNA; Triplex-forming oligonucleotides; Catalytic nucleic …
Nucleic Acid-Based Strategies to Treat Neurodegenerative Diseases
S Panda, O Chatterjee, S Chatterjee - … Acid Biology and its Application in …, 2023 - Springer
Last few decades unveiled the existence of diverse pool of non-coding RNAs, small RNAs,
and repetitive elements which can play a pivotal role in maintaining the cellular homeostasis …
and repetitive elements which can play a pivotal role in maintaining the cellular homeostasis …
New insights: microRNA function in CNS development and psychiatric diseases
Q Liu, L Zhang, H Li - Current Pharmacology Reports, 2018 - Springer
Abstract Purpose of Review Here, we concisely review microRNA (miRNA)-related research
publications on the central nervous system (CNS) development (focusing on the forebrain …
publications on the central nervous system (CNS) development (focusing on the forebrain …
Widespread functional opsin transduction in the rat cortex via convection-enhanced delivery optimized for horizontal spread
Z Yu, A Nurmikko, I Ozden - Journal of Neuroscience Methods, 2017 - Elsevier
Background Widespread opsin expression in the cortex of rats, where transgenic models
have not been established, is not practical to achieve with the traditional diffusion-based …
have not been established, is not practical to achieve with the traditional diffusion-based …
Targeting age-related neurodegenerative diseases by AAV-Mediated gene therapy
U Cagin - Reviews on New Drug Targets in Age-Related …, 2021 - Springer
Age-related neurodegenerative diseases have detrimental consequences on health of many
patients and result in mortality. The current treatment options are limited and usually fail to …
patients and result in mortality. The current treatment options are limited and usually fail to …
Cryoprecipitate augments the global transduction of the adeno-associated virus serotype 9 after a systemic administration
Z Chai, X Zhang, KM Rigsbee, M Wang… - Journal of controlled …, 2018 - Elsevier
Adeno-associated virus (AAV) vectors have been successfully used for transgene delivery in
clinical trials. A systemic administration of AAV vectors has been proposed in order to …
clinical trials. A systemic administration of AAV vectors has been proposed in order to …
Modulatory polynucleotides
DWY Sah, J Hou, ME Nonnenmacher - US Patent 11,193,129, 2021 - Google Patents
2020-02-07 Assigned to VOYAGER THERAPEUTICS, INC. reassignment VOYAGER
THERAPEUTICS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …
THERAPEUTICS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …
An engineered serum albumin-binding AAV9 capsid achieves improved liver transduction after intravenous delivery in mice
Q Jin, C Qiao, J Li, J Li, X Xiao - Gene Therapy, 2020 - nature.com
Recombinant adeno-associated viral (AAV) vectors are frequently used to deliver DNA into
cells and are currently the leading platform for therapeutic gene delivery in humans …
cells and are currently the leading platform for therapeutic gene delivery in humans …
AADC polynucleotides for the treatment of parkinson's disease
US10335466B2 - AADC polynucleotides for the treatment of parkinson's disease - Google
Patents US10335466B2 - AADC polynucleotides for the treatment of parkinson's disease …
Patents US10335466B2 - AADC polynucleotides for the treatment of parkinson's disease …
Modulatory polynucleotides
J Hou, ME Nonnenmacher, P Zhou - US Patent 11,198,873, 2021 - Google Patents
C12N15/113—Non-coding nucleic acids modulating the expression of genes, eg antisense
oligonucleotides; Antisense DNA or RNA; Triplex-forming oligonucleotides; Catalytic nucleic …
oligonucleotides; Antisense DNA or RNA; Triplex-forming oligonucleotides; Catalytic nucleic …