Immune privilege of the central nervous system (CNS) has been ascribed to the presence of
a blood–brain barrier and the lack of lymphatic vessels within the CNS parenchyma …

Tracers injected into CSF pass into the brain alongside arteries and out again. This has
been recently termed the “glymphatic system” that proposes tracers enter the brain along …

This review considers efflux of substances from brain parenchyma quantified as values of
clearances (CL, stated in µL g− 1 min− 1). Total clearance of a substance is the sum of …

The human brain is the organ with the highest metabolic activity but it lacks a traditional
lymphatic system responsible for clearing waste products. We have demonstrated that the …

Alzheimer's disease (AD) is characterized by β-amyloid plaques and intraneuronal τ
aggregation usually associated with cerebral amyloid angiopathy (CAA). Both β-amyloid …

Meninges that surround the CNS consist of an outer fibrous sheet of dura mater
(pachymeninx) that is also the inner periosteum of the skull. Underlying the dura are the …

Stroke and Alzheimer's disease (AD) are cerebral pathologies with high socioeconomic
impact that can occur together and mutually interact. Vascular factors predisposing to …

Two of the key functions of arteries in the brain are (1) the well‐recognized supply of blood
via the vascular lumen and (2) the emerging role for the arterial walls as routes for the …

Deposition of amyloid β (Aβ) in the walls of cerebral arteries as cerebral amyloid angiopathy
(CAA) suggests an age-related failure of perivascular drainage of soluble Aβ from the brain …

The cerebral vasculature is made up of highly specialized structures that assure constant
brain perfusion necessary to meet the very high demand for oxygen and glucose by neurons …