Alzheimer disease (AD) is the first progressive neurodegenerative disease worldwide, and
the disease is characterized by an accumulation of amyloid in the brain and …

How solutes and macromolecules are removed from brain tissue is of central importance in
normal brain physiology and in how toxic protein aggregates are cleared in …

White matter abnormalities on magnetic resonance imaging (MRI) are associated with
dementia and include white matter hyperintensities (WMH; also termed leukoaraiosis) and …

Background: Cerebrovascular disease is a common comorbidity in patients with Alzheimer's
disease (AD). It is believed to contribute additively to the cognitive impairment and to lower …

Alzheimer disease neuropathology is characterized by the extracellular accumulation of Aβ
peptide and intracellular aggregation of hyperphosphorylated tau. With the progression of …

Cerebral amyloid angiopathy (CAA) is an important cerebral small vessel disease
associated with brain haemorrhage and cognitive change. The commonest form, sporadic …

Alzheimer's Disease (AD) and atherosclerosis remain two of the largest public health
burdens in the world today. Although traditionally considered distinct pathological entities …

In Alzheimer's disease, amyloid‐β (Aβ) accumulates as insoluble plaques in the brain and
deposits in blood vessel walls as cerebral amyloid angiopathy (CAA). The severity of CAA …

Despite the absence of conventional lymphatics, there is efficient drainage of both
cerebrospinal fluid (CSF) and interstitial fluid (ISF) from the CNS to regional lymph nodes …

Rapid progress is being made in understanding the roles of the cerebral meninges in the
maintenance of normal brain function, in immune surveillance, and as a site of disease. Most …