Correct annotation metadata is critical for reproducible and accurate RNA-seq analysis.
When files are shared publicly or among collaborators with incorrect or missing annotation …

In recent years, the role of bioinformatics and computational biology together with omics
techniques and transcriptomics has gained tremendous importance in biomedicine and …

Mutations disrupting the nuclear localization of the RNA-binding protein FUS characterize a
subset of amyotrophic lateral sclerosis patients (ALS-FUS). FUS regulates nuclear RNAs …

Gene mutations causing cytoplasmic mislocalization of the RNA-binding protein FUS lead to
severe forms of amyotrophic lateral sclerosis (ALS). Cytoplasmic accumulation of FUS is …

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease,
characterized by the death of upper (UMN) and lower motor neurons (LMN) in the motor …

Human cellular models of neurodegeneration require reproducibility and longevity, which is
necessary for simulating age-dependent diseases. Such systems are particularly needed for …

Background With the cost of DNA sequencing decreasing, increasing amounts of RNA-Seq
data are being generated giving novel insight into gene expression and regulation. Prior to …

We have previously demonstrated that systemic AMP-activated protein kinase α1 (AMPKα1)
invalidation enhanced adverse LV remodelling by increasing fibroblast proliferation, while …

Periodontitis is a chronic inflammatory oral disease that affects approximately 42% of adults
30 years of age or older in the United States. In response to microbial dysbiosis within the …

Sequencing databases contain enormous amounts of functional genomics data, making
them an extensive resource for genome-scale analysis. Reanalyzing publicly available data …