Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration

S Kuchen, R Robbins, GP Sims, C Sheng… - The journal of …, 2007 - journals.aai.org
During T cell-B cell collaboration, plasma cell (PC) differentiation and Ig production are
known to require T cell-derived soluble factors. However, the exact nature of the cytokines …

Mapping gene regulatory networks of primary CD4+ T cells using single-cell genomics and genome engineering

RE Gate, MC Kim, A Lu, D Lee, E Shifrut… - bioRxiv, 2019 - biorxiv.org
Gene regulatory programs controlling the activation and polarization of CD4+ T cells are
incompletely mapped and the interindividual variability in these programs remain unknown …

Fundamentals and control of stochastic decision-making in HIV

Y Lu - 2022 - ideals.illinois.edu
Human immunodeficiency virus (HIV), the virus responsible for the current acquired
immunodeficiency syndrome (AIDS) epidemic, infects and destroys many different cell types …

Natural and synthetic genetic regulation in stimulated CD4+ T cells

RE Gate - 2019 - escholarship.org
Over 90% of genetic variants associated with complex human traits map to non-coding
regions, but little is understood about how they modulate gene regulation in health and …

[图书][B] Regulation of the immune response studied in vitro

AM Varey - 1991 - search.proquest.com
In an attempt to study the regulation of the immune response in vitro, different agents have
been used. Some appear to affect proliferation and/or differentiation of B cells and some …