Over the past decade, the emergence of effective immunotherapies has revolutionized the
clinical management of many types of cancers. However, long-term durable tumour control …

Characterization of RNA modifications has identified their distribution features and
molecular functions. Dynamic changes in RNA modification on various forms of RNA are …

As the most abundant and conserved internal modification in eukaryote RNAs, N6-
methyladenosine (m6A) is involved in a wide range of physiological and pathological …

Excessive cytokine activity underlies many autoimmune conditions, particularly through the
interleukin-17 (IL-17) and tumor necrosis factor–α (TNFα) signaling axis. Both cytokines …

Viral reproduction is contingent on viral protein synthesis that relies on the host ribosomes.
As such, viruses have evolved remarkable strategies to hijack the host translational …

Abstract N 6-methyladenosine (m6A) modification is a dynamic, reversible process and is
the most prevalent internal modification of RNA. This modification is regulated by three …

Posttranscriptional modifications have been implicated in regulation of nearly all biological
aspects of cellular RNAs, from stability, translation, splicing, nuclear export to localization …

Recent discoveries have revealed that, during viral infection, the presence of the RNA
modification N 6-methyladenosine (m 6 A) on viral and cellular RNAs has profound impacts …

Among over 150 distinct RNA modifications, N 6-methyladenosine (m6A) and adenosine-to-
inosine (A-to-I) RNA editing represent 2 of the most studied modifications on mammalian …

Chemical modifications of mRNA, the so-called epitranscriptome, represent an additional
layer of post-transcriptional regulation of gene expression. The most common …