[HTML][HTML] mRNA vaccine era—mechanisms, drug platform and clinical prospection
S Xu, K Yang, R Li, L Zhang - International journal of molecular sciences, 2020 - mdpi.com
Messenger ribonucleic acid (mRNA)-based drugs, notably mRNA vaccines, have been
widely proven as a promising treatment strategy in immune therapeutics. The extraordinary …
widely proven as a promising treatment strategy in immune therapeutics. The extraordinary …
[HTML][HTML] Biocompatibility, biodegradation and biomedical applications of poly (lactic acid)/poly (lactic-co-glycolic acid) micro and nanoparticles
Background Poly (lactic acid)(PLA) and poly (lactic-co-glycolic acid)(PLGA) are among the
well-documented FDA-approved polymers used for the preparation of safe and effective …
well-documented FDA-approved polymers used for the preparation of safe and effective …
The challenge and prospect of mRNA therapeutics landscape
Messenger RNA (mRNA)-based therapeutics hold the potential to cause a major revolution
in the pharmaceutical industry because they can be used for precise and individualized …
in the pharmaceutical industry because they can be used for precise and individualized …
Adjuvant-pulsed mRNA vaccine nanoparticle for immunoprophylactic and therapeutic tumor suppression in mice
Synthetic mRNA represents an exciting cancer vaccine technology for the implementation of
effective cancer immunotherapy. However, inefficient in vivo mRNA delivery along with a …
effective cancer immunotherapy. However, inefficient in vivo mRNA delivery along with a …
Nano-bio interactions in mRNA nanomedicine: Challenges and opportunities for targeted mRNA delivery
Upon entering the biological milieu, nanomedicines swiftly interact with the surrounding
tissue fluid, subsequently being enveloped by a dynamic interplay of biomacromolecules …
tissue fluid, subsequently being enveloped by a dynamic interplay of biomacromolecules …
[HTML][HTML] mRNA vaccine: a potential therapeutic strategy
Y Wang, Z Zhang, J Luo, X Han, Y Wei, X Wei - Molecular cancer, 2021 - Springer
Abstract mRNA vaccines have tremendous potential to fight against cancer and viral
diseases due to superiorities in safety, efficacy and industrial production. In recent decades …
diseases due to superiorities in safety, efficacy and industrial production. In recent decades …
Ionizable lipid nanoparticles encapsulating barcoded mRNA for accelerated in vivo delivery screening
PPG Guimaraes, R Zhang, R Spektor, M Tan… - Journal of Controlled …, 2019 - Elsevier
Messenger RNA (mRNA) has recently emerged as a promising class of nucleic acid therapy,
with the potential to induce protein production to treat and prevent a range of diseases …
with the potential to induce protein production to treat and prevent a range of diseases …
Nanoplatforms for mRNA therapeutics
C Meng, Z Chen, G Li, T Welte… - Advanced Therapeutics, 2021 - Wiley Online Library
Abstract mRNA‐based therapeutics are a unique class of drugs for treatment of human
diseases. Since in vitro transcribed mRNA molecules have relatively low stability and their …
diseases. Since in vitro transcribed mRNA molecules have relatively low stability and their …
[HTML][HTML] Lipid carriers for mRNA delivery
W Zhang, Y Jiang, Y He, H Boucetta, J Wu… - … Pharmaceutica Sinica B, 2023 - Elsevier
Messenger RNA (mRNA) is the template for protein biosynthesis and is emerging as an
essential active molecule to combat various diseases, including viral infection and cancer …
essential active molecule to combat various diseases, including viral infection and cancer …
[HTML][HTML] mRNA therapeutic modalities design, formulation and manufacturing under pharma 4.0 principles
In the quest for a formidable weapon against the SARS-CoV-2 pandemic, mRNA
therapeutics have stolen the spotlight. mRNA vaccines are a prime example of the benefits …
therapeutics have stolen the spotlight. mRNA vaccines are a prime example of the benefits …